BV2

Rhodamine B-labelled BV2 (10 mg/kg; i.v.; single dose) demonstrates strong muscle-homing ability in wild-type C57BL/6 mice, with preferential accumulation in cardiac and skeletal tissues after single intravenous administration of 10 mg/kg^[1].
BV2-mCherry (20 mg/kg; i.v.; single dose) effectively delivers mCherry protein to peripheral skeletal muscle cells in wild-type C57BL/6 mice after single intravenous administration of 20 mg/kg, with minimal accumulation in non-muscle tissues^[1].
Rhodamine B-labelled BV2 (100 μg per microneedle patch; local implantation; single application; 2 hours), delivered via HA microneedle implantation, effectively accumulates in and is internalized by local skeletal muscle cells in wild-type C57BL/6 mice after a single 2-hour application of a 100 μg-loaded patch^[1].
BV2-mCherry (150 μg per microneedle patch; local implantation; single application), delivered via HA microneedle implantation, effectively promotes mCherry protein delivery to skeletal muscle layers in wild-type C57BL/6 mice after a single application of a 150 μg-loaded patch^[1].
BV2-E31R (50 μg per microneedle patch; local implantation; 3 times per week; 2 weeks), delivered via HA microneedle implantation at 50 μg per patch 3 times weekly for 2 weeks, significantly increases muscle mass and myofibre size in both immobilization- and denervation-induced skeletal muscle atrophy mice^[1].
EXOBV2&PMO (12.5 mg/kg/week PMO equivalent; i.v.; weekly; 3 weeks), administered intravenously at 12.5 mg/kg/week PMO equivalent for 3 weeks, significantly restores dystrophin expression (up to 10-fold increase in triceps), enhances muscle grip strength, and reduces muscle damage in adult mdx mice^[1].
EXOBV2&PMO (25 mg/kg/week PMO equivalent; i.v.; weekly; 3 weeks), administered intravenously at 25 mg/kg/week PMO equivalent for 3 weeks, achieves near-normal dystrophin restoration in peripheral muscles, partial cardiac dystrophin restoration, and significant phenotypic rescue (improved grip strength, reduced muscle damage) in adult DKO mice without detectable organ toxicity^[1].