CD2665
Based on 2 publication(s) in Google Scholar
CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.68%
- CAS. Nr.: 170355-78-9
- Formel: C31H34O5
- Molecular Weight:486.60
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Orally Active Compound Library
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Publications Citing Use of MedChemExpress (MCE) CD2665
More
Biologische Aktivität
Ki: 110 nM (RARγ), 306 nM (RARβ)[1]
CD2665 (100 nM; 9 days; 3T3 cells) has significant effects on cell growth and differentiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3 cells
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Concentration:100 nM
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Incubation Time:9 days
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Result:Abrogated the antiprolferative effects of ATRA , CD271 (adapalene, an RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level.
CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice submitted to 10 months of ethanol consumption[2].
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Dosage:0.6 mg/kg
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Administration:Subcutaneous injection; daily, for 22 days.
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Result:Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.
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Animal Model:Male and female mice (3 weeks)[3].
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Dosage:1.6 mg/kg
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Administration:Oral gavage/intragastric; daily, for 31 days.
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Result:Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.
Chemical Information
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CAS. Nr. 170355-78-9
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Appearance Solid
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Molecular Weight 486.60
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Formel C31H34O5
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Color White to off-white
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SMILES
COCCOCOC1=CC2=CC=C(C3=CC=C(C(O)=O)C=C3)C=C2C=C1C45C[C@H](C6)C[C@H](C[C@H]6C5)C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Biomaterials
Transduction enhancing EF-C peptide nanofibrils are endocytosed by macropinocytosis and subsequently degraded. [Abstract]2025 Jun:317:123044. PMID: 39754968 -
Clin Transl Med
ZSH-2208: A novel retinoid with potent anti-tumour effects on ESCC stem cells via RARγ-TNFAIP3 axis. [Abstract]2025 Jan;15(1):e70148. PMID: 39724264
Lösungsmittel & Löslichkeit
DMSO : 62.5 mg/mL (128.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Kim MJ, et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J Invest Dermatol. 2000 Feb;114(2):349-53. [Content Brief]
[2]. Alfos S, Boucheron C, et al. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alcohol Clin Exp Res. 2001 Oct;25(10):1506-14. [Content Brief]
[3]. Koyama E, et al.Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co-Administration of a Retinoid Antagonist in Mice. J Bone Miner Res. 2021 Jul;36(7):1387-1402. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0551 mL | 10.2754 mL | 20.5508 mL | 51.3769 mL |
| 5 mM | 0.4110 mL | 2.0551 mL | 4.1102 mL | 10.2754 mL | |
| 10 mM | 0.2055 mL | 1.0275 mL | 2.0551 mL | 5.1377 mL | |
| 15 mM | 0.1370 mL | 0.6850 mL | 1.3701 mL | 3.4251 mL | |
| 20 mM | 0.1028 mL | 0.5138 mL | 1.0275 mL | 2.5688 mL | |
| 25 mM | 0.0822 mL | 0.4110 mL | 0.8220 mL | 2.0551 mL | |
| 30 mM | 0.0685 mL | 0.3425 mL | 0.6850 mL | 1.7126 mL | |
| 40 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2844 mL | |
| 50 mM | 0.0411 mL | 0.2055 mL | 0.4110 mL | 1.0275 mL | |
| 60 mM | 0.0343 mL | 0.1713 mL | 0.3425 mL | 0.8563 mL | |
| 80 mM | 0.0257 mL | 0.1284 mL | 0.2569 mL | 0.6422 mL | |
| 100 mM | 0.0206 mL | 0.1028 mL | 0.2055 mL | 0.5138 mL |
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