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Art. -Nr.: HY-181919

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CD73-IN-22

CD73-IN-22 (Compound HX-6) is a non-nucleoside CD73 inhibitor with an IC₅₀ of 0.07 μM. When radiolabeled with ⁶⁸Ga, CD73-IN-22 acts as a PET radiotracer for detecting CD73 expression. When radiolabeled with ¹⁷⁷Lu, CD73-IN-22 exhibits anticancer activity against colorectal adenocarcinoma. CD73-IN-22 is applicable to research related to colon adenocarcinoma and breast cancer.

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Formel: C₄₃H₄₅FN₁₂O₉
Molecular Weight:892.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CD73-IN-22 Chemical Structure

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 0.07 μM (CD73)^[1]

Alle Radionuclide-Drug Conjugates (RDCs) Isoform-spezifische Produkte anzeigen :

In Vitro

CD73-IN-22 potently inhibits the enzymatic activity of CD73, with an IC₅₀ of 0.07 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 892.89
Formel C₄₃H₄₅FN₁₂O₉
SMILES

OC(CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(N2N=CC3=C2C=C(N4C(C=C(C5=CC=NN5CC6=CC=C(C#N)C=C6)C=C7F)=C7N=N4)C=C3)=O)C(O)=O)CC1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhao C, et al. Design, synthesis and preclinical evaluation of a tumor extracellular nucleotidase CD73 targeted theranostic radiotracer. Eur J Med Chem. 2026;308:118728. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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CD73-IN-22

Alle Radionuclide-Drug Conjugates (RDCs) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CD73-IN-22 Related Classifications

HY-181919 Related Classifications