Ceapin-A7
Based on 24 publication(s) in Google Scholar
Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 2323027-38-7
- Formula: C20H12F6N4O3
- Molecular Weight:470.32
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
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HY-L090
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HY-L099
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HY-L138
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Publications Citing Use of MedChemExpress (MCE) Ceapin-A7
More- Signal Transduct Target Ther. 2024 Dec 30;9(1):367. [Abstract]
- Cancer Res. 2021 Oct 15;81(20):5325-5335. [Abstract]
- J Hazard Mater. 2024 May 5:469:134061. [Abstract]
- Cell Mol Biol Lett. 2022 Dec 16;27(1):110. [Abstract]
- J Transl Med. 2025 Aug 5;23(1):860. [Abstract]
- Cell Death Discov. 2026 Feb 26. [Abstract]
- Mol Med. 2024 Nov 29;30(1):237. [Abstract]
- Liver Int. 2024 May;44(5):1219-1232. [Abstract]
- Int J Mol Sci. 2026 Jan 25;27(3):1213. [Abstract]
- Biomolecules. 2026 Apr;16(4):506.
- mBio. 2025 Dec 5:e0324225. [Abstract]
- Toxicology. 2024 Aug 6:153906. [Abstract]
- Fish Shellfish Immunol. 2024 Nov 9:155:110020. [Abstract]
- Cytokine. 2026 Jan:197:157068. [Abstract]
- Cell Signal. 2024 Dec 8:127:111560. [Abstract]
- Am J Pathol. 2026 Mar 19:S0002-9440(26)00065-9. [Abstract]
- Am J Pathol. 2024 Jan;194(1):85-100. [Abstract]
- Vet Microbiol. 2024 May:292:110051. [Abstract]
- Biochem Biophys Res Commun. 2024 Nov 12:733:150716. [Abstract]
- bioRxiv. 2026 May 29:2026.05.26.727520. [Abstract]
- bioRxiv. 2026 Feb 1:2026.01.28.702376. [Abstract]
- bioRxiv. 2026 Feb 24.
- Temple University. 2025.
- bioRxiv. 2024 August 28.
Customer Validation & Images
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RT-PCR
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WB
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Flow Cytometry
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WB
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WB
Biological Activity
0.59 μM (ATF6α)[1]
Chemical Information
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CAS No. 2323027-38-7
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Appearance Solid
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Molecular Weight 470.32
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Formula C20H12F6N4O3
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Color Off-white to light yellow
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SMILES
O=C(NC1=CN(CC2=CC=C(C(F)(F)F)C=C2C(F)(F)F)N=C1)C3=NOC(C4=CC=CO4)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 2 years -20°C 1 year
Publications (24)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2024 Dec 30;9(1):367. PMID: 39737965
Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Dec 30;9(1):367. [Abstract]
Il1b, Tnfa, or Il6 mRNA expressions in LPS-stimulated BMDMs treated with/without L-malate (24 h) in the presence or absence of CEAPIN-A7 (CEAPIN, 8 μM).
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Cancer Res
Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers. [Abstract]2021 Oct 15;81(20):5325-5335. PMID: 34548333 -
J Hazard Mater
A new insight into Cd exposure-induced hemocyte reduction in Lymantria dispar larvae: Involvement of the ROS-ATF6-ER stress-apoptosis pathway. [Abstract]2024 May 5:469:134061. PMID: 38508113 -
Cell Mol Biol Lett
Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress. [Abstract]2022 Dec 16;27(1):110. PMID: 36526973
Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2022 Dec 16;27(1):110. [Abstract]
Immunoblot of GRP78 and CHOP under insulin and PA combined treatment with or without pre-treatment of ATF6α inhibitor Ceapin-A7 (6 μM), PERK inhibitor ISRIB (0.2 μM) and IRE1 inhibitor 4μ8C (50 μM).
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J Transl Med
Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer. [Abstract]2025 Aug 5;23(1):860. PMID: 40764992
Ceapin-A7 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Aug 5;23(1):860. [Abstract]
ATF6 inhibition abolished the effect of RAD51 down-regulation mediated by IVA. 5 μM of ATF6 inhibitor Ceapin-A7, 0.1 µM of IVA and 5 μM of OLA were used. The cells were treated for 72 h. Western blot was performed. HSP90 was the loading control. the results showed that Ceapin-A7 increased RAD51-EGFP levels.
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Cell Death Discov
Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells. [Abstract]2026 Feb 26. PMID: 41748537 -
Mol Med
MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway. [Abstract]2024 Nov 29;30(1):237. PMID: 39614150
Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Nov 29;30(1):237. [Abstract]
After treating with Ceapin-A7 (6 µM) for 1 h and stimulating with rhMIF for 3 days, flow cytometry was used to analyze the effect of Ceapin-A7 on Th17 cells. *ρ < 0.05
Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Nov 29;30(1):237. [Abstract]
The expression of ATF6α, STAT3, and RORC in RA patient cells stimulated with rhMIF in the presence of Ceapin-A7 （6 µM; 1 h）.
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Liver Int
Mitochondrial amidoxime-reducing component 1 p.Ala165Thr increases protein degradation mediated by the proteasome. [Abstract]2024 May;44(5):1219-1232. PMID: 38375985 -
Int J Mol Sci
Cartilage Intermediate Layer Protein 2 Aggravates Hepatic Lipid Accumulation and Inflammation Through the IRE1α/XBP1 Pathway. [Abstract]2026 Jan 25;27(3):1213. PMID: 41683641 -
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mBio
Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication. [Abstract]2025 Dec 5:e0324225. PMID: 41347792 -
Toxicology
Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways. [Abstract]2024 Aug 6:153906. PMID: 39117261 -
Fish Shellfish Immunol
Grass Carp Reovirus (GCRV) infection activates the PERK-eIF2α pathway to promote the viral replication. [Abstract]2024 Nov 9:155:110020. PMID: 39528019 -
Cytokine
Triptolide impacts CSF1R expression and reprograms the suppressive function of myeloid-derived suppressor cells via targeting the ER stress pathway. [Abstract]2026 Jan:197:157068. PMID: 41197245 -
Cell Signal
Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer. [Abstract]2024 Dec 8:127:111560. PMID: 39657838 -
Am J Pathol
R-Propranolol Promotes the Adipogenesis and Subsequent Apoptosis of Hemangioma Stem Cells through the Protein Kinase RNA-Like Endoplasmic Reticulum Kinase Signaling Pathway. [Abstract]2026 Mar 19:S0002-9440(26)00065-9. PMID: 41864339 -
Am J Pathol
Sleep Deprivation Impairs Intestinal Mucosal Barrier by Activating Endoplasmic Reticulum Stress in Goblet Cells. [Abstract]2024 Jan;194(1):85-100. PMID: 37918798 -
Vet Microbiol
Bovine parainfluenza virus type 3 infections induce ER stress-mediated autophagy to facilitate virus replication. [Abstract]2024 May:292:110051. PMID: 38513524 -
Biochem Biophys Res Commun
Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1/JNK-induced ferroptosis. [Abstract]2024 Nov 12:733:150716. PMID: 39321486 -
bioRxiv
2026 May 29:2026.05.26.727520. PMID: 42244578 -
bioRxiv
The active secretion of a subunit of IL-12 by tissue cells is regulated by Valosin-Containing Protein and intracellular calcium redistribution. [Abstract]2026 Feb 1:2026.01.28.702376. PMID: 41659431 -
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Solvent & Solubility
DMSO : 100 mg/mL (212.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (5.32 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 12.5 mg/mL (26.58 mM); Suspended solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1262 mL | 10.6311 mL | 21.2621 mL | 53.1553 mL |
| 5 mM | 0.4252 mL | 2.1262 mL | 4.2524 mL | 10.6311 mL | |
| 10 mM | 0.2126 mL | 1.0631 mL | 2.1262 mL | 5.3155 mL | |
| 15 mM | 0.1417 mL | 0.7087 mL | 1.4175 mL | 3.5437 mL | |
| 20 mM | 0.1063 mL | 0.5316 mL | 1.0631 mL | 2.6578 mL | |
| 25 mM | 0.0850 mL | 0.4252 mL | 0.8505 mL | 2.1262 mL | |
| 30 mM | 0.0709 mL | 0.3544 mL | 0.7087 mL | 1.7718 mL | |
| 40 mM | 0.0532 mL | 0.2658 mL | 0.5316 mL | 1.3289 mL | |
| 50 mM | 0.0425 mL | 0.2126 mL | 0.4252 mL | 1.0631 mL | |
| 60 mM | 0.0354 mL | 0.1772 mL | 0.3544 mL | 0.8859 mL | |
| 80 mM | 0.0266 mL | 0.1329 mL | 0.2658 mL | 0.6644 mL | |
| 100 mM | 0.0213 mL | 0.1063 mL | 0.2126 mL | 0.5316 mL |
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