Art. -Nr.: HY-111820

CK1-IN-1

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Based on 1 publication(s) in Google Scholar

CK1-IN-1 (Compound 1c) is a casein kinase 1 (CK1) inhibitor with IC₅₀ values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC₅₀ of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis.

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Reinheit: 99.19%
CAS. Nr.: 1784751-20-7
Formel: C₂₄H₁₅F₂N₃
Molecular Weight:383.39

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

CK1-IN-1 Chemical Structure

CAS. Nr.: 1784751-20-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

CK1δ

15 nM (IC₅₀)

CK1ε

16 nM (IC₅₀)

p38α MAPK

73 nM (IC₅₀)

Alle Casein Kinase Isoform-spezifische Produkte anzeigen :

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

In Vitro

CK1-IN-1 has a stronger inhibitory activity against Casein Kinase 1 (CK1) than p38α MAPK, with IC₅₀ values of 15 nM and 16 nM for CK1δ and CK1ε, respectively, and an IC₅₀ value of 73 nM for p38α MAPK^[1].
CK1-IN-1 (5 µM) fails to effectively promote the differentiation of human embryonic stem cells (hESC3) into cardiomyocytes and does not significantly increase the expression of Nkx2.5 green fluorescent protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1784751-20-7
Appearance Solid
Molecular Weight 383.39
Formel C₂₄H₁₅F₂N₃
Color Light yellow to yellow
SMILES

FC1=CC=C(C2=C(C3=CC=NC=C3)NC(C4=CC=C5C=CC=CC5=C4F)=N2)C=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Journal Impact Factor

Neuron

Cell-type-focused compound screen in human organoids reveals CK1 inhibition protects cone photoreceptors from death. [Abstract]

2026 Jul 1;114(13):2347-2366.e12. PMID: 41916277

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 62.5 mg/mL (163.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6083 mL

13.0415 mL

26.0831 mL

5 mM

0.5217 mL

2.6083 mL

5.2166 mL

10 mM

0.2608 mL

1.3042 mL

2.6083 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Filip LACO,et al. 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis. WO2015119579A1.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6083 mL	13.0415 mL	26.0831 mL	65.2077 mL
	5 mM	0.5217 mL	2.6083 mL	5.2166 mL	13.0415 mL
	10 mM	0.2608 mL	1.3042 mL	2.6083 mL	6.5208 mL
	15 mM	0.1739 mL	0.8694 mL	1.7389 mL	4.3472 mL
	20 mM	0.1304 mL	0.6521 mL	1.3042 mL	3.2604 mL
	25 mM	0.1043 mL	0.5217 mL	1.0433 mL	2.6083 mL
	30 mM	0.0869 mL	0.4347 mL	0.8694 mL	2.1736 mL
	40 mM	0.0652 mL	0.3260 mL	0.6521 mL	1.6302 mL
	50 mM	0.0522 mL	0.2608 mL	0.5217 mL	1.3042 mL
	60 mM	0.0435 mL	0.2174 mL	0.4347 mL	1.0868 mL
	80 mM	0.0326 mL	0.1630 mL	0.3260 mL	0.8151 mL
	100 mM	0.0261 mL	0.1304 mL	0.2608 mL	0.6521 mL

Keywords

CK1-IN-1

1 Cited Publications

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CK1-IN-1

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Publications Citing Use of MedChemExpress (MCE) CK1-IN-1

Alle Casein Kinase Isoform-spezifische Produkte anzeigen

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CK1-IN-1 Related Classifications

HY-111820 Related Classifications