CP-17
CP-17 is a potent and selective IDH2/R140Q inhibitor with an IC50 of 40.75 nM. CP-17 exhibits excellent selectivity of >55-fold against the wild-type IDH2. CP-17 exhibits robust D-2-HG suppression activity in TF-1 (IDH2/R140Q) cells and reverses the cellular differentiation block induced by the R140Q mutation. CP-17 can be used for acute myeloid leukemia (AML) research.
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- CAS. Nr.: 1111233-06-7
- Formel: C25H25ClN4O2
- Molecular Weight:448.94
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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IDH2-R140Q 40.75 nM (IC50) |
Chemical Information
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CAS. Nr. 1111233-06-7
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Molecular Weight 448.94
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Formel C25H25ClN4O2
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SMILES
O=C(NC1=CC(Cl)=CC=C1C)NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2N4CCCC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CP-17 Related Classifications
HY-145743 Related Classifications
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