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Art. -Nr.: HY-131923

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DAPM

DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells.

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CAS. Nr.: 208255-51-0
Formel: C₂₀H₂₀F₂N₂O₄
Molecular Weight:390.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DAPM Chemical Structure

CAS. Nr.: 208255-51-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	12 μM Compound: DAPM	Antiproliferative activity against human HCT116 cells after 72 hrs by SYBR green dye based fluorescence assay Antiproliferative activity against human HCT116 cells after 72 hrs by SYBR green dye based fluorescence assay	[PMID: 30201292]

Chemical Information

CAS. Nr. 208255-51-0
Molecular Weight 390.38
Formel C₂₀H₂₀F₂N₂O₄
Sequence

N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine methyl ester
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Miyamoto S, et al. Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis. 2013 Oct;34(10):2415-23. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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DAPM

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

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DAPM Related Classifications

HY-131923 Related Classifications