DC-BPi-11
DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.
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- CAS. Nr.: 2758411-61-7
- Formel: C20H23N5O2S
- Molecular Weight:397.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
698 nM (BPTF)[1]
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Cell Line
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Type | Value | Description | References |
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| MV4-11 | IC50 |
0.89 μM
Compound: DC-BPi-11
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Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
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[PMID: 34375106] |
DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM[1].
DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression[1].
DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level[1].
DC-BPi-11 is safety and shows minimal effects on normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human leukemia MV-4-11 cells
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Concentration:0.6 μM, 1.8 μM, 5.6 μM, 16.6 μM, and 50 μM
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Incubation Time:24 hours
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Result:Resulted depletion of c-Myc in a dose-dependent manner.
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Cell Line:Human leukemia MV-4-11 cells
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:24 hours
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Result:Induced cell apoptosis by arresting cell cycle at G1 phase.
Chemical Information
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CAS. Nr. 2758411-61-7
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Molecular Weight 397.49
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Formel C20H23N5O2S
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SMILES
CN(C)CCCN1C=CC2=C1C=CC(C3=NC(S(C)(=O)=O)=NC4=C3C=CN4)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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