Diclofenac ethyl ester
Based on 1 Customer Validation
Diclofenac ethyl ester is the prodrug of Diclofenac (HY-15036), that is encapsulated in polymer micelles in vitro, and released with prolonged circulation time and reduced drug concentrations in the heart and kidneys in vivo.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.28%
- CAS. Nr.: 15307-77-4
- Formel: C16H15Cl2NO2
- Molecular Weight:324.20
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 15307-77-4
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Appearance Solid
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Molecular Weight 324.20
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Formel C16H15Cl2NO2
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Color White to off-white
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SMILES
ClC1=C(C(Cl)=CC=C1)N(C2=C(C=CC=C2)CC(OCC)=O)[H]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (154.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0845 mL | 15.4226 mL | 30.8452 mL | 77.1129 mL |
| 5 mM | 0.6169 mL | 3.0845 mL | 6.1690 mL | 15.4226 mL | |
| 10 mM | 0.3085 mL | 1.5423 mL | 3.0845 mL | 7.7113 mL | |
| 15 mM | 0.2056 mL | 1.0282 mL | 2.0563 mL | 5.1409 mL | |
| 20 mM | 0.1542 mL | 0.7711 mL | 1.5423 mL | 3.8556 mL | |
| 25 mM | 0.1234 mL | 0.6169 mL | 1.2338 mL | 3.0845 mL | |
| 30 mM | 0.1028 mL | 0.5141 mL | 1.0282 mL | 2.5704 mL | |
| 40 mM | 0.0771 mL | 0.3856 mL | 0.7711 mL | 1.9278 mL | |
| 50 mM | 0.0617 mL | 0.3085 mL | 0.6169 mL | 1.5423 mL | |
| 60 mM | 0.0514 mL | 0.2570 mL | 0.5141 mL | 1.2852 mL | |
| 80 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9639 mL | |
| 100 mM | 0.0308 mL | 0.1542 mL | 0.3085 mL | 0.7711 mL |
Diclofenac ethyl ester Related Classifications
HY-127125 Related Classifications
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