Dideoxycytidinene
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Dideoxycytidinene (2′,3′-Didehydro-2′,3′-dideoxycytidine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.36%
- CAS. Nr.: 7481-88-1
- Formel: C9H11N3O3
- Molecular Weight:209.20
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ATH-8 cell line | ED50 |
0.3 μM
Compound: 2b
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Protection of ATH8 cells against the cytopathic effect of HIV.
Protection of ATH8 cells against the cytopathic effect of HIV.
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[PMID: 3497272] |
| CCRF-CEM | ED50 |
>20 μM
Compound: 1
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In vitro concentration required to decrease 50% of mitochondrial DNA content in CEM cells
In vitro concentration required to decrease 50% of mitochondrial DNA content in CEM cells
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[PMID: 8627596] |
| CCRF-CEM | ED50 |
20 μM
Compound: 1
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In vitro concentration required to inhibit 50% of CEM cell growth
In vitro concentration required to inhibit 50% of CEM cell growth
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[PMID: 8627596] |
| HepG2 | ED50 |
10 nM
Compound: 1
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Concentration required to inhibit 50% of extracellular circular replication of HBV DNA using 2215 cell line
Concentration required to inhibit 50% of extracellular circular replication of HBV DNA using 2215 cell line
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[PMID: 8627596] |
| HepG2 | ED50 |
8 nM
Compound: 1
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Concentration required to inhibit 50% of intracellular circular replication of HBV DNA using 2215 cell line
Concentration required to inhibit 50% of intracellular circular replication of HBV DNA using 2215 cell line
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[PMID: 8627596] |
| MT2 | ED50 |
1 μM
Compound: 1
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Concentration required to inhibit 50% of HIV activity in MT-2 cells
Concentration required to inhibit 50% of HIV activity in MT-2 cells
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[PMID: 8627596] |
| MT4 | ED50 |
0.13 μM
Compound: d4Cyd
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Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
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[PMID: 2342078] |
Chemical Information
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CAS. Nr. 7481-88-1
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Appearance Solid
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Molecular Weight 209.20
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Formel C9H11N3O3
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Color White to light yellow
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SMILES
OC[C@@H]1C=C[C@H](N2C(N=C(N)C=C2)=O)O1
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Synonyms
2′,3′-Didehydro-2′,3′-dideoxycytidine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Dideoxycytidinene Related Classifications
HY-145791 Related Classifications
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