Art. -Nr.: HY-121524

DJ101

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DJ101 is a potent and metabolically stable tubulin inhibitor. DJ101 targets the colchicine binding site and overcomes taxane resistance. DJ101 also inhibits melanoma tumor growth and lung metastasis. DJ101 can be used for prostate cancer research.

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Reinheit: 99.36%
CAS. Nr.: 1803242-21-8
Formel: C₂₃H₂₀N₄O₃
Molecular Weight:400.43

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DJ101 Chemical Structure

CAS. Nr.: 1803242-21-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	3 nM Compound: 41	Cytotoxicity against human A375 cells after 48 hrs by MTS assay Cytotoxicity against human A375 cells after 48 hrs by MTS assay	[PMID: 26396686]
DU-145	IC₅₀	14 nM Compound: 41	Cytotoxicity against human DU145 cells after 48 hrs by MTS assay Cytotoxicity against human DU145 cells after 48 hrs by MTS assay	[PMID: 26396686]
DU-145	IC₅₀	17 nM Compound: 41	Cytotoxicity against human paclitaxel-resistant DU145 cells after 48 hrs by MTS assay Cytotoxicity against human paclitaxel-resistant DU145 cells after 48 hrs by MTS assay	[PMID: 26396686]
M14	IC₅₀	14 nM Compound: 41	Cytotoxicity against human M14 cells after 48 hrs by MTS assay Cytotoxicity against human M14 cells after 48 hrs by MTS assay	[PMID: 26396686]
PC-3	IC₅₀	12 nM Compound: 41	Cytotoxicity against human paclitaxel-resistant PC3 cells after 48 hrs by MTS assay Cytotoxicity against human paclitaxel-resistant PC3 cells after 48 hrs by MTS assay	[PMID: 26396686]
PC-3	IC₅₀	7 nM Compound: 41	Cytotoxicity against human PC3 cells after 48 hrs by MTS assay Cytotoxicity against human PC3 cells after 48 hrs by MTS assay	[PMID: 26396686]

Chemical Information

CAS. Nr. 1803242-21-8
Appearance Solid
Molecular Weight 400.43
Formel C₂₃H₂₀N₄O₃
Color Light yellow to yellow
SMILES

COC1=C(OC)C(OC)=CC(C2=NC=CC3=C2N=C(C4=CC=CC5=C4C=CN5)N3)=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (249.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4973 mL

12.4866 mL

24.9732 mL

5 mM

0.4995 mL

2.4973 mL

4.9946 mL

10 mM

0.2497 mL

1.2487 mL

2.4973 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.24 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (6.24 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Arnst KE, Wang Y, Hwang DJ, et al. A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. Cancer Res. 2018;78(1):265-277. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4973 mL	12.4866 mL	24.9732 mL	62.4329 mL
	5 mM	0.4995 mL	2.4973 mL	4.9946 mL	12.4866 mL
	10 mM	0.2497 mL	1.2487 mL	2.4973 mL	6.2433 mL
	15 mM	0.1665 mL	0.8324 mL	1.6649 mL	4.1622 mL
	20 mM	0.1249 mL	0.6243 mL	1.2487 mL	3.1216 mL
	25 mM	0.0999 mL	0.4995 mL	0.9989 mL	2.4973 mL
	30 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0811 mL
	40 mM	0.0624 mL	0.3122 mL	0.6243 mL	1.5608 mL
	50 mM	0.0499 mL	0.2497 mL	0.4995 mL	1.2487 mL
	60 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0405 mL
	80 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7804 mL
	100 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL

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DJ101

MCE Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DJ101 Related Classifications

HY-121524 Related Classifications