Art. -Nr.: HY-121026

DMNQ

Name: DMNQ
Brand: MedChemExpress
SKU: HY-121026
Price: 75.00 USD
Availability: InStock
Rating: 5 (8 reviews)

8 Cited Publications

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Based on 8 publication(s) in Google Scholar

DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production.

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Reinheit: 98.69%
CAS. Nr.: 6956-96-3
Formel: C₁₂H₁₀O₄
Molecular Weight:218.21

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DMNQ Chemical Structure

CAS. Nr.: 6956-96-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (8)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production^[1]^[2].

IC₅₀ & Target

γ-glutamylcysteine synthetase (γ-GCs)^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	15.6 μM Compound: 15	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
AGS	IC₅₀	9.1 μM Compound: 3	Antitumor against human AGS cells after 72 hrs by MTT assay Antitumor against human AGS cells after 72 hrs by MTT assay	[PMID: 18299197]
HL-60	IC₅₀	5.4 μM Compound: 15	Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
HL-60	IC₅₀	8.9 μM Compound: 3	Antitumor against human HL60 cells after 72 hrs by MTT assay Antitumor against human HL60 cells after 72 hrs by MTT assay	[PMID: 18299197]
J82	IC₅₀	16.1 μM Compound: 3	Antitumor against human J82 cells after 72 hrs by MTT assay Antitumor against human J82 cells after 72 hrs by MTT assay	[PMID: 18299197]
Jurkat	IC₅₀	11.5 μM Compound: 15	Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
LS174T	IC₅₀	27.9 μM Compound: 15	Cytotoxicity against human LS174T cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human LS174T cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MCF7	IC₅₀	6.3 μM Compound: 15	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MONO-MAC-6	IC₅₀	3.6 μM Compound: 15	Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human MONO-MAC-6 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
MRC5	IC₅₀	7.2 μM Compound: 3	Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay	[PMID: 18299197]
PBMC	IC₅₀	18.5 μM Compound: 15	Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
SK-MES-1	IC₅₀	5.3 μM Compound: 3	Antitumor against human SK-MES1 cells after 72 hrs by MTT assay Antitumor against human SK-MES1 cells after 72 hrs by MTT assay	[PMID: 18299197]
SW982	IC₅₀	20.6 μM Compound: 15	Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human SW982 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
THP-1	IC₅₀	8.2 μM Compound: 15	Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]
U-937	IC₅₀	11.3 μM Compound: 15	Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human U937 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 31563013]

In Vitro

DMNQ (20-100 μM; 30 min) can induce H₂O₂ production in a concentration-dependent manner in A549-S cells^[1].
DMNQ (5-10 μM; 0-24 h) can increase glutathione (GSH) (physiological antioxidant) content in L2 cells in a time- and dose-dependent manner by enhancing the activity of γ-glutamylcysteine synthetase (γ-GCs) (70%) ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

L2
Concentration:

5 μM, 10 μM
Incubation Time:

24 h
Result:

Increased the level of γGCS-HS protein.

Chemical Information

CAS. Nr. 6956-96-3
Appearance Solid
Molecular Weight 218.21
Formel C₁₂H₁₀O₄
Color Light yellow to yellow
SMILES

O=C1C(OC)=C(C(C2=CC=CC=C21)=O)OC
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (8)

All RT-PCR

Sort by:

Journal Impact Factor

Immunity

Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease. [Abstract]

2021 Aug 10;54(8):1728-1744.e7. PMID: 34343498
Adv Sci (Weinh)

ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling. [Abstract]

2026 Mar;13(16):e13310. PMID: 41589654
EMBO J

A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress. [Abstract]

2023 Oct 16;42(20):e113743. PMID: 37661833
Food Funct

Investigating the neuroprotective effects of polyunsaturated fatty acids in egg yolk phospholipids upon oxidative damage in HT22 cells. [Abstract]

2025 Jul 28;16(15):6051-6063. PMID: 40341910
Int J Mol Sci

Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature. [Abstract]

2023 Dec 28;25(1):423. PMID: 38203594
Mol Med Rep

Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway. [Abstract]

2025 Jul;32(1):186. PMID: 40314092
Am J Pathol

Targeting N-Cadherin and Tubulin α 1A in Neuroblastoma Bone Marrow Metastasis: Insights from Single-Cell Analysis and Drug Screening. [Abstract]

2026 Mar;196(3):816-835. PMID: 41485549
Mediators Inflamm

CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF- κ B Pathway. [Abstract]

2020 Jun 6:2020:4321912. PMID: 32587470

DMNQ purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2020 Jun 6:2020:4321912. [Abstract]

qPCR shows that the levels of IL-6, IL-1β, and TNF-α in DMNQ group increased compared with the M5580 group, indicating that DMNQ could weaken the inhibitory effect of M5580 on inflammation production.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (229.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5827 mL

22.9137 mL

45.8274 mL

5 mM

0.9165 mL

4.5827 mL

9.1655 mL

10 mM

0.4583 mL

2.2914 mL

4.5827 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (11.46 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (11.46 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Watanabe N, et al. Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells. Arch Biochem Biophys. 2003 Mar 1;411(1):145-57. [Content Brief]

[2]. Shi MM, et al. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. J Biol Chem. 1994 Oct 21;269(42):26512-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.5827 mL	22.9137 mL	45.8274 mL	114.5685 mL
	5 mM	0.9165 mL	4.5827 mL	9.1655 mL	22.9137 mL
	10 mM	0.4583 mL	2.2914 mL	4.5827 mL	11.4569 mL
	15 mM	0.3055 mL	1.5276 mL	3.0552 mL	7.6379 mL
	20 mM	0.2291 mL	1.1457 mL	2.2914 mL	5.7284 mL
	25 mM	0.1833 mL	0.9165 mL	1.8331 mL	4.5827 mL
	30 mM	0.1528 mL	0.7638 mL	1.5276 mL	3.8190 mL
	40 mM	0.1146 mL	0.5728 mL	1.1457 mL	2.8642 mL
	50 mM	0.0917 mL	0.4583 mL	0.9165 mL	2.2914 mL
	60 mM	0.0764 mL	0.3819 mL	0.7638 mL	1.9095 mL
	80 mM	0.0573 mL	0.2864 mL	0.5728 mL	1.4321 mL
	100 mM	0.0458 mL	0.2291 mL	0.4583 mL	1.1457 mL

Bioz

Keywords

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CAS. Nr.:
Species:
Reinheit:
Menge:

DMNQ

Mitoquinone mesylate

MitoPQ

Z-VAD-FMK

Staurosporine

Tunicamycin

L-Glutathione reduced

β-Lapachone

Coelenterazine

CADD522

Methoxy-PMS

Succinobucol

CycLuc1

Publications Citing Use of MedChemExpress (MCE) DMNQ

Biologische Aktivität

Chemical Information

Publications (8)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

DMNQ

Mitoquinone mesylate

MitoPQ

Z-VAD-FMK

Staurosporine

Tunicamycin

L-Glutathione reduced

β-Lapachone

Coelenterazine

CADD522

Methoxy-PMS

Succinobucol

CycLuc1

Publications Citing Use of MedChemExpress (MCE) DMNQ

Biologische Aktivität

Chemical Information

Publications (8)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DMNQ Related Classifications

HY-121026 Related Classifications

Bioz