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Art. -Nr.: HY-184332

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DNMT3A-IN-4

DNMT3A-IN-4 is a DNMT3A inhibitor with an IC₅₀ of 33.4 μM against human DNMT3A. DNMT3A-IN-4 inhibits the proliferation of colorectal cancer cells and can be used for the research of colorectal cancer.

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Formel: C₂₀H₁₅N₅O₃
Molecular Weight:373.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DNMT3A-IN-4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

DNMT3A

33.4 μM (IC₅₀)

Alle DNA Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

DNMT3A-IN-4 (compound 6o) (100-320 μM; 1 h) preferentially inhibits recombinant human DNMT3A/3L over DNMT1, and shows only weak inhibitory activity against DNMT1 even at concentrations as high as 320 μM^[1].
DNMT3A-IN-4 (25-150 μM; 24-72 h) does not reduce the viability of HCT116 colorectal cancer cells^[1].
DNMT3A-IN-4 (100 μM; 24 h) does not reduce the protein abundance of DNMT1 or DNMT3A in HCT116 colorectal cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 373.36
Formel C₂₀H₁₅N₅O₃
SMILES

O=C1NC2=C(C(C3=CC=C(N4C=CN=C4)C=C3)C5=C(O2)C=C(O)C=C5)C(N)=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chen T, et al. Rational design and synthesis of a heterocycle scaffold for DNMT3A inhibition. Bioorganic chemistry. 2026 Sep 05;179:110025. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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DNMT3A-IN-4

Alle DNA Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

DNMT3A-IN-4 Related Classifications

HY-184332 Related Classifications

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