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Efgartigimod alfa

(Synonyms: ARGX-113)
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Efgartigimod alfa (ARGX-113) is a reversibility, humanized Fc receptor antagonist . Efgartigimod alfa is a anti FcRn monoclonal immunoglobulin G (IgG1) Fc fragment. Efgartigimod reduces serum levels of total IgG, including pathogenic autoantibodies, by blocking FcRn function without permanent impairment. Efgartigimod alfa can be used for generalised myasthenia gravis (gMG) and primary immune thrombocytopenia research.

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  • Reinheit: 98.48%
  • CAS. Nr.: 1821402-21-4
  • Molecular Weight:51.28 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Efgartigimod alfa
  • Experimental Validation Results for Efgartigimod alfa
  • Experimental Validation Results for Efgartigimod alfa
  • Efgartigimod alfa Chemical Structure
    Efgartigimod alfa Chemical Structure
CAS. Nr.: 1821402-21-4
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Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    FC-GAMMA-1

  • 1/16

    Immobilized FCGRT Protein, Human (GST, HY-P72192) can bind Efgartigimod alfa. The EC50 for this effect is 535.9 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 THP-1 cells with Efgartigimod alfa (HY-147305, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. cells without incubation with primary antibody were used as the unlabeled control (black).

  • Efgartigimod alfa Chemical Structure
    1/16
  • Efgartigimod alfa
  • Immobilized FCGRT Protein, Human (GST, HY-P72192) can bind Efgartigimod alfa. The EC50 for this effect is 535.9 ng/mL.
  • Flow cytometric analysis of 1X106 THP-1 cells with Efgartigimod alfa (HY-147305, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. cells without incubation with primary antibody were used as the unlabeled control (black).
  • FC-GAMMA-1