Erinacine C
Based on 1 publication(s) in Google Scholar
Erinacine C is the inhibitor for NF-κB signaling pathway and the activator for Nrf2 signaling pathway. Erinacine C exhibits antioxidant, neuroprotective and anti-inflammatory effects.
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- Reinheit: 99.27%
- CAS. Nr.: 156101-09-6
- Formel: C25H38O6
- Molecular Weight:434.57
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Erinacine C
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Biologische Aktivität
Beschreibung
In Vitro
Erinacine C (0.1-10 µM, 24 h) inhibits the cell growth of BV2 microglia, reduces the production of NO, IL-6 and TNF-α, and promotes the expression of HO-1 in LPS (HY-D1056)-stimulated BV2 microglia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mild traumatic brain injury (mTBI) rat model[3]
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Dosage:2 mg/kg
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Administration:ip, once daily for 5 days
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Result:Reduced the time in the balance beam walking test.
Increased the number of normal neurons in the brain tissue.
Chemical Information
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CAS. Nr. 156101-09-6
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Appearance Solid
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Molecular Weight 434.57
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Formel C25H38O6
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Color White to off-white
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SMILES
C[C@]12C([C@]3([H])[C@]([C@]4([H])[C@@](O[C@@]5([H])[C@](OC[C@H]([C@@H]5O)O)([H])O4)([H])C(CO)=CC3)(CC1)C)=C(CC2)C(C)C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Molecules
Polysorbate 80 Differentially Impacts Erinacine Production Profiles in Submerged Cultures of Hericium. [Abstract]2025 Jun 30;30(13):2823. PMID: 40649339
Lösungsmittel & Löslichkeit
In Vitro:
Ethanol : 10 mg/mL (23.01 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Hiromichi Kenmoku, et al. Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete. Biosci Biotechnol Biochem. 2002 Mar;66(3):571-5. [Content Brief]
[2]. Wang LY, et al., Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS. Molecules. 2019 Sep 12;24(18):3317. [Content Brief]
[3]. Lee KF, et al., The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways. Antioxidants (Basel). 2024 Mar 19;13(3):371. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.3011 mL | 11.5056 mL | 23.0113 mL | 57.5281 mL |
| 5 mM | 0.4602 mL | 2.3011 mL | 4.6023 mL | 11.5056 mL | |
| 10 mM | 0.2301 mL | 1.1506 mL | 2.3011 mL | 5.7528 mL | |
| 15 mM | 0.1534 mL | 0.7670 mL | 1.5341 mL | 3.8352 mL | |
| 20 mM | 0.1151 mL | 0.5753 mL | 1.1506 mL | 2.8764 mL |
Erinacine C Related Classifications
HY-N11004 Related Classifications
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