F16 (Standard)
F16 (Standard) is the analytical standard of F16 (HY-100395). This product is intended for research and analytical applications. F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 36098-33-6
- Formel: C16H15IN2
- Molecular Weight:362.21
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS. Nr. 36098-33-6
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Molecular Weight 362.21
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Formel C16H15IN2
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SMILES
C[N+]1=CC=C(/C=C/C2=CNC3=C2C=CC=C3)C=C1.[I-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Fantin VR, et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer cell. 2002 Jul;2(1):29-42. [Content Brief]
[2]. Fantin VR, et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer research. 2004 Jan 01;64(1):329-36. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
F16 (Standard) Related Classifications
HY-100395R Related Classifications
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Keywords
- F16 (Standard)
- 36098-33-6
- Reference Standards
- Mitochondrial Metabolism
- Reactive Oxygen Species (ROS)
- Akt
- p38 MAPK
- Bcl-2 Family
- Apoptosis
- Bcl-2
- carcinoma cell mitochondria
- MAP kinase
- normal mammary epithelial cells
- human breast cancer cells
- PKB/Akt
- nude mice
- mitochondrial permeability transition pore
- Neu
- EpH4-A6 neu-overexpressing mouse mammary epithelial cells
- Inhibitor
- inhibitor
- inhibit