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Art. -Nr.: HY-123113

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Fazarabine

Name: Fazarabine
Brand: MedChemExpress
SKU: HY-123113
Availability: PreOrder

(Synonyms: Kymarabine; Ara-AC; NSC 281272)

Fazarabine (Kymarabine; Ara-AC; NSC 281272) is an orally active, blood-brain barrier permeable DNA polymerase inhibitor and antitumor agent. Fazarabine interferes with DNA synthesis via intracellular activation into a triphosphate nucleotide that directly incorporates into DNA, inducing cytotoxicity, myelosuppression, as well as moderate nausea and vomiting. Fazarabine is resistant to deamination by cytidine-deoxycytidine deaminase and undergoes spontaneous aqueous degradation. Fazarabine exerts time-dependent, broad-spectrum activity against leukemia and solid tumors. Fazarabine can be used in research related to refractory malignancies, acute leukemia, and blast-phase chronic myeloid leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 65886-71-7
Formel: C₈H₁₂N₄O₅
Molecular Weight:244.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fazarabine Chemical Structure

CAS. Nr.: 65886-71-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

DNA Polymerases

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLT-4	IC50	0.1 μM	Inhibition of clonogenic survival against human Molt-4 T-lymphoblastic leukemia cells in a 24 h in vitro clonogenic survival assay. Inhibition of clonogenic survival against human Molt-4 T-lymphoblastic leukemia cells in a 24 h in vitro clonogenic survival assay.	2475244

In Vitro

Anti-cancer

Fazarabine (0.1-1 μM; 24 h) reduces the clonogenic survival rate of the human T-lymphoblastic leukemia cell line Molt-4: after 24 h of exposure, the inhibition rate reaches 50% at 0.1 μM and 98% at 1 μM^[1].
Fazarabine exhibits broad-spectrum antitumor activity against the P388 and L1210 cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Fazarabine (administered every 3 hours; dosed on days 1, 5, and 9; once daily; maximum treatment duration of 9 days) exhibits in vivo antileukemic activity against mouse L1210 and P388 leukemia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 65886-71-7
Molecular Weight 244.20
Formel C₈H₁₂N₄O₅
SMILES

NC(N=CN1[C@H]2[C@@H](O)[C@H](O)[C@@H](CO)O2)=NC1=O
Synonyms

Kymarabine; Ara-AC; NSC 281272
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Heideman RL, et al. Phase I trial and pharmacokinetic evaluation of fazarabine in children. Cancer research. 1989 Sep 15;49(18):5213-6.

[2]. Wilhelm M, et al. Phase I study of arabinosyl-5-azacytidine (fazarabine) in adult acute leukemia and chronic myelogenous leukemia in blastic phase. Leukemia & lymphoma. 1999 Aug;34(5-6):511-8.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Fazarabine

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