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Art. -Nr.: HY-119060

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FP0429

FP0429 is a full mGlu4 agonist and partial mGlu8 agonist with EC₅₀ values of 48.3 μM and 56.2 μM, respectively.

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CAS. Nr.: 870860-41-6
Formel: C₁₀H₁₂N₂O₇
Molecular Weight:272.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

FP0429 Chemical Structure

CAS. Nr.: 870860-41-6

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

FP0429 is a full mGlu4 agonist and partial mGlu8 agonist with EC₅₀ values of 48.3 μM and 56.2 μM, respectively^[1].

Alle mGluR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>5000 μM Compound: 8a06, FP0429	Activity at rat mGluR2 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR2 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	>5000 μM Compound: 8a06, FP0429	Activity at rat mGluR5 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR5 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	378 μM Compound: 8a06, FP0429	Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	48.3 μM Compound: 8a06, FP0429	Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	56.2 μM Compound: 8a06, FP0429	Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]
HEK293	EC₅₀	>5000 μM Compound: 8a06, FP0429	Activity at rat mGluR1 receptor measured as intracellular calcium concentration in HEK293 cells Activity at rat mGluR1 receptor measured as intracellular calcium concentration in HEK293 cells	[PMID: 16828551]

Chemical Information

CAS. Nr. 870860-41-6
Molecular Weight 272.21
Formel C₁₀H₁₂N₂O₇
SMILES

O=C(O)[C@H]1N(C[C@@](N)(C1)C(O)=O)C(/C=C/C(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Schann S, et al. Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4856-60. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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FP0429

Alle mGluR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

FP0429 Related Classifications

HY-119060 Related Classifications