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Cry2 - cryptochrome 2 (photolyase-like) Gene

Also Known as D130054K12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12953

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. [provided by RefSeq, Feb 2014]

Cry2 Products (1)

mRNA	Protein	Name
NM_009963.4	NP_034093.1	cryptochrome-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables FAD binding	IDA IDA: Inferred from direct assay	23503662	MGI
enables kinase binding	IPI IPI: Inferred from physical interaction	24158435	MGI
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	22170608	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14701732	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20123978	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21680841	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in circadian regulation of gene expression	IGI IGI: Inferred from genetic interaction	22170608	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19299583	MGI
acts upstream of or within circadian rhythm	IMP IMP: Inferred from mutant phenotype	12024206	MGI
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	20123978	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	23616524	MGI
involved in glucose homeostasis	IGI IGI: Inferred from genetic interaction	22170608	MGI
involved in lipid storage	IGI IGI: Inferred from genetic interaction	23531614	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12738229	MGI
involved in negative regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	22170608	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28683290	MGI
involved in negative regulation of circadian rhythm	IDA IDA: Inferred from direct assay	19605937	MGI
involved in negative regulation of glucocorticoid receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22170608	MGI
involved in negative regulation of glucocorticoid secretion	IGI IGI: Inferred from genetic interaction	23531614	MGI
acts upstream of or within protein import into nucleus	IPI IPI: Inferred from physical interaction	15689618	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	10217146	MGI
involved in response to activity	IMP IMP: Inferred from mutant phenotype	28683290	MGI
involved in response to insulin	IGI IGI: Inferred from genetic interaction	23531614	MGI
involved in response to light stimulus	IMP IMP: Inferred from mutant phenotype	29561690	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Cry-Per complex	IPI IPI: Inferred from physical interaction	20840750	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	9801304	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9801304	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cryptochrome-2

Cry2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Cry2	Q9R194	Fbxl3	Mus musculus	Q8C4V4	Anti Tag CoIP	23452855
Intra	Cry2	Q9R194	Fbxl3	Mus musculus	Q8C4V4	Anti Tag CoIP	17462724
Intra	Cry2	Q9R194	Per1	Mus musculus	O35973	Y2H	24737000
Intra	Cry2	Q9R194	Per2	Mus musculus	O54943	Anti Bait CoIP	22170608
Intra	Cry2	Q9R194	Per2	Mus musculus	O54943	Y2H	20840750
Intra	Cry2	Q9R194	Nr3c1	Mus musculus	P06537-1	Anti Bait CoIP	22170608
Cross	Cry2	Q9R194	FBXL3	Homo sapiens	Q9UKT7	GMS	23503662
Cross	Cry2	Q9R194	FBXL3	Homo sapiens	Q9UKT7	Ion Exchange Chrom	23503662
Cross	Cry2	Q9R194	FBXL3	Homo sapiens	Q9UKT7	X-Ray Diffraction	23503662
Cross	Cry2	Q9R194	FBXL3	Homo sapiens	Q9UKT7	Anti Tag CoIP	23503662
Cross	Cry2	Q9R194	FBXL3	Homo sapiens	Q9UKT7	Pull Down	23503662
Cross	Cry2	Q9R194	FBXL3	Homo sapiens	Q9UKT7	SLCA	23503662
Cross	Cry2	Q9R194	PER1	Homo sapiens	O15534	Anti Tag CoIP	23503662
Intra	Cry2	Q9R194	Bmal1	Mus musculus	Q9WTL8	Y2H	24737000
Intra	Cry2	Q9R194	Fbxl21	Mus musculus	Q8BFZ4	Anti Tag CoIP	23452856
Intra	Cry2	Q9R194	Fbxl21	Mus musculus	Q8BFZ4	Anti Tag CoIP	23452855

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-108468	KL001		99.06%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-134194	KL201		98.18%	Unkown
HY-134192	TH301		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cry2	NCBI	NCBI:1408