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LNX2 - ligand of numb-protein X 2 Gene

Also Known as PDZRN1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 222484

About LNX2

Cytogenetic location: 13q12.2 Genomic coordinates (GRCh38): 13:27,545,913-27,621,107 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 9.5), small intestine (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

LNX2 Products (1)

mRNA	Protein	Name
NM_153371.4	NP_699202.1	ligand of Numb protein X 2

LNX2 Protein Structure

zf-C3HC4

PDZ

0
200
400
600
690 a.a.

Protein Preferred Names	Protein Names
ligand of Numb protein X 2	PDZ domain containing ring finger 1

LNX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	LNX2	Q8N448	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	LNX2	Q8N448	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	LNX2	Q8N448	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	LNX2	Q8N448	SCLY	Homo sapiens	Q96I15	Y2H	21516116
Intra	LNX2	Q8N448	PEG10	Homo sapiens	Q86TG7	Y2H	21516116
Intra	LNX2	Q8N448	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	LNX2	Q8N448	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	LNX2	Q8N448	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	LNX2	Q8N448	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	LNX2	Q8N448	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	LNX2	Q8N448	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	LNX2	Q8N448	ATP5F1B	Homo sapiens	P06576	Y2H Array	29892012
Intra	LNX2	Q8N448	ATP5F1B	Homo sapiens	P06576	Y2H Array	31515488
Cross	LNX2	Q8N448	Hoxa1	Mus musculus	P09022	Y2H	23088713
Cross	LNX2	Q8N448	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Intra	LNX2	Q8N448	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	LNX2	Q8N448	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	LNX2	Q8N448	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	LNX2	Q8N448	MYLIP	Homo sapiens	Q8WY64	Y2H Array	31515488
Intra	LNX2	Q8N448	PAAT	Homo sapiens	Q9H8K7	Y2H Array	31515488
Intra	LNX2	Q8N448	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	LNX2	Q8N448	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	LNX2	Q8N448	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	LNX2	Q8N448	PTCD3	Homo sapiens	Q96EY7	Y2H	21516116
Intra	LNX2	Q8N448	FHL3	Homo sapiens	Q13643	Validated Y2H	27107012
Intra	LNX2	Q8N448	IP6K2	Homo sapiens	Q9UHH9	Y2H	21516116
Intra	LNX2	Q8N448	OPTN	Homo sapiens	Q96CV9	Y2H	21516116
Intra	LNX2	Q8N448	PHYKPL	Homo sapiens	Q8IUZ5	Y2H Array	31515488
Intra	LNX2	Q8N448	CBX5	Homo sapiens	P45973	Y2H Array	32814053
Intra	LNX2	Q8N448	CBX5	Homo sapiens	P45973	Y2H Pooling	32814053
Intra	LNX2	Q8N448	CBX5	Homo sapiens	P45973	Validated Y2H	32814053
Cross	LNX2	Q8N448	tax	Human T-cell leukemia virus	P03410	Y2H Pooling	22458338
Cross	LNX2	Q8N448	tax	Human T-cell leukemia virus	P03410	Y2H Array	22458338
Cross	LNX2	Q8N448	rex_htl1c	Human T-cell leukemia virus 1	P0C206	Y2H Pooling	22458338
Cross	LNX2	Q8N448	rex_htl1c	Human T-cell leukemia virus 1	P0C206	Y2H Array	22458338
Cross	LNX2	Q8N448	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Q Fever	Infection Due To Coxiella Burnetii Quadrilateral Fever Query Fever Nine Mile Fever Coxiella Burnetii Fever Q Fever Pneumonia Coxiellosis Pneumonia In Q Fever Australian Q Fever Balkan Grippe
Neutropenia, Severe Congenital, X-Linked	X-Linked Severe Congenital Neutropenia XLN SCNX Severe Congenital Neutropenia X-Linked Neutropenia, Congenital, Severe, X-Linked
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07733	LNX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LNX2	RGD	RGD:1308222
Macaca mulatta	LNX2	VGNC	VGNC:106268
Felis catus	LNX2	VGNC	VGNC:63254
Bos taurus	LNX2	VGNC	VGNC:30946
Canis familiaris	LNX2	VGNC	VGNC:42732
Mus musculus	LNX2	MGD	MGI:2155959
Others	LNX2	NCBI