GCLM - glutamate-cysteine ligase modifier subunit Gene

Also Known as GLCLR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2730

About GCLM

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,885,199-93,909,430 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 13.0), thyroid (RPKM 9.9) and 24 other tissues.

Summary

Glutamate-cysteine Ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GCLM Products (2)

mRNA	Protein	Name
NM_001308253.2	NP_001295182.1	glutamate--cysteine ligase regulatory subunit isoform 2
NM_002061.4	NP_002052.1	glutamate--cysteine ligase regulatory subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
contributes to glutamate-cysteine ligase activity	IMP IMP: Inferred from mutant phenotype	16183645	GOA
enables glutamate-cysteine ligase catalytic subunit binding	IPI IPI: Inferred from physical interaction	9675072	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9675072	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	12975258	GOA
involved in glutamate metabolic process	IDA IDA: Inferred from direct assay	9841880	GOA
involved in glutathione biosynthetic process	IDA IDA: Inferred from direct assay	9675072	GOA
involved in glutathione biosynthetic process	IMP IMP: Inferred from mutant phenotype	12081989	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	10395918	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	9895302	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of glutamate-cysteine ligase complex	IDA IDA: Inferred from direct assay	9675072	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCLM Protein Structure

Aldo_ket_red

0
100
200
274 a.a.

Protein Preferred Names	Protein Names
glutamate--cysteine ligase regulatory subunit	GCS light chain

GCLM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	GCLM	P48507	GCLC	Homo sapiens	P48506	Anti Tag CoIP	33961781
Intra	GCLM	P48507	GCLC	Homo sapiens	P48506	Chromatography	9675072
Intra	GCLM	P48507	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GCLM Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81662	GCLM Antibody (YA1407)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P86557	GCLM Antibody (YA6249)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Parkinson Disease 4, Autosomal Dominant	Autosomal Dominant Parkinson Disease 4 PARK4 Parkinson Disease 4, Autosomal Dominant Lewy Body Parkinson Disease 4 Parkinson'S Disease 4 Autosomal Dominant Lewy Body Parkinson Disease 4 Autosomal Dominant Parkinson'S Disease 4 Parkinson Disease 4 Autosomal Dominant Lewy Body Parkinson Disease Autosomal Dominant 4 Parkinson Disease Familial Type 4 Parkinson Disease, Type 4
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-W015600	2-Acetamidophenol		99.73%	Unkown
HY-171705	KMS99220		99.48%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-121523	MIND4-17	Activator	99.05%	Unkown
HY-W015600S	2-Acetamidophenol-d3		99.48%	Unkown
HY-172598	SG16	Inhibitor	/	Unkown
HY-181907	NBE5		/	Unkown
HY-RS05334	GCLM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18936	Gclm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25426	Gclm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GCLM	VGNC	VGNC:41148
Rattus norvegicus	GCLM	RGD	RGD:619871
Bos taurus	GCLM	VGNC	VGNC:29290
Felis catus	GCLM	VGNC	VGNC:80218
Macaca mulatta	GCLM	VGNC	VGNC:72924
Mus musculus	GCLM	MGD	MGI:104995
Others	GCLM	NCBI