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SLC25A5 - solute carrier family 25 member 5 Gene

Also Known as T2; T3; 2F1; AAC2; ANT2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 292

About SLC25A5

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:119,468,444-119,471,396 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 49 paralogues. Ubiquitous expression in duodenum (RPKM 370.1), small intestine (RPKM 299.2) and 25 other tissues.

Summary

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce Apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

SLC25A5 Products (1)

mRNA	Protein	Name
NM_001152.5	NP_001143.2	ADP/ATP translocase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables adenine nucleotide transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	19116139	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17715127	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in adenine nucleotide transport	IMP IMP: Inferred from mutant phenotype	19116139	GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19154410	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19154410	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of MMXD complex	IDA IDA: Inferred from direct assay	20797633	GOA
located in membrane	IDA IDA: Inferred from direct assay	27641616	GOA
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	18063578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A5 Protein Structure

Mito_carr

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
ADP/ATP translocase 2	adenine nucleotide translocator 2 (fibroblast)

SLC25A5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SLC25A5	P05141	SIRT4	Homo sapiens	Q9Y6E7	Anti Tag CoIP	17715127
Intra	SLC25A5	P05141	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	21370995
Intra	SLC25A5	P05141	SLC35F6	Homo sapiens	Q8N357	Anti Tag CoIP	19154410

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Hypertension And Brachydactyly Syndrome	Brachydactyly With Hypertension Bilginturan Syndrome HTNB Brachydactyly-Arterial Hypertension Syndrome Brachydactyly, Type E, With Short Stature And Hypertension Bilginturan Brachydactyly Brachydactyly Type E With Short Stature And Hypertension Type E Brachydactyly With Short Stature And Hypertension Brachydactyly Type E, With Short Stature And Hypertension Hypertension With Brachydactyly
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13131	SLC25A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20216	Slc25a5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26723	Slc25a5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC25A5	VGNC	VGNC:54599
Rattus norvegicus	SLC25A5	RGD	RGD:620353
Bos taurus	SLC25A5	VGNC	VGNC:49966
Mus musculus	SLC25A5	MGD	MGI:1353496
Others	SLC25A5	NCBI