CD99 - CD99 molecule (Xg blood group) Gene

Also Known as MIC2; HBA71; MIC2X; MIC2Y; MSK5X

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4267

About CD99

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:2,691,295-2,741,309 (from NCBI)

This gene has 15 transcripts (splice variants), 154 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 38.2), gall bladder (RPKM 35.8) and 25 other tissues.

Summary

The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin Cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]

CD99 Products (6)

mRNA	Protein	Name
NM_001122898.3	NP_001116370.1	CD99 antigen isoform b precursor
NM_001321367.2	NP_001308296.1	CD99 antigen isoform c precursor
NM_001321368.2	NP_001308297.1	CD99 antigen isoform d precursor
NM_001321369.2	NP_001308298.1	CD99 antigen isoform e precursor
NM_001321370.2	NP_001308299.1	CD99 antigen isoform f precursor
NM_002414.5	NP_002405.1	CD99 antigen isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20374249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD99 Protein Structure

CD99L2

0
100
185 a.a.

Protein Preferred Names	Protein Names
CD99 antigen	E2 antigen

Recombinant CD99 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70752	CD99 Protein, Human (HEK293, Fc)	P14209-1 (D23-D122)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77623	CD99 Protein, Human (HEK293, His)	P14209-1 (D23-D122)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78896	CD99 Protein, Human (Biotinylated, HEK293, His-Avi)	P14209-1 (D23-D122)	≥ 90%, as determined by reducing SDS-PAGE.

CD99 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80070	CD99 Antibody (YA522)	WB, ICC/IF, IHC-P, IP, FC	Human
HY-P84094	CD99 Antibody (YA3791)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84094A	CD99 Antibody (YA3791)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84095	CD99 Antibody (YA3792)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84095A	CD99 Antibody (YA3792)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Extraosseous Ewing Sarcoma	Extraosseous Ewing'S Sarcoma Extraosseous Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Extraskeletal Ewing Sarcom Sarcoma Extraosseous Ewings Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Lymphoblastic Lymphoma	Lymphoma, Lymphoblastic Lymphoma Lymphoblastic Precursor Cell Lymphoblastic Lymphoma Precursor Cell Lymphoblastic Leukemia Lymphoma
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Intracranial Primitive Neuroectodermal Tumor	Intracranial Pnet Intracranial Primitive Neuroectodermal Neoplasm
Testicular Fibroma
Mixed Endometrial Stromal And Smooth Muscle Tumor	Stromomyoma Mixed Endometrial Stromal And Smooth Muscle Neoplasm
Askin'S Tumor	Askin Tumor Askin Tumour Askin'S Tumour
Epidural Spinal Canal Neoplasm	Extradural Tumor Epidural Neoplasms Epidural Neoplasm
Myocardium Cancer	Malignant Myocardial Tumor Malignant Neoplasm Of Myocardium Tumor Of Myocardium Malignant Tumor Of Myocardium
Cerebellopontine Angle Primitive Neuroectodermal Tumor	Cerebellopontine Angle Pnet
Colon Carcinoma In Situ	Carcinoma In Situ Of Colon Stage 0 Colonic Carcinoma Stage 0 Carcinoma Of Colon Intraepithelial Neoplasia Of Colon, High Grade Carcinoma In Situ Of Cecum Carcinoma In Situ Of Hepatic Flexure Carcinoma In Situ Of Ileocecal Valve Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor	Extraosseous Ewing'S Tumor Extraosseous Ewing'S Tumour Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumour
Ectomesenchymoma	Rhabdomyosarcoma With Ganglionic Differentiation Malignant Ectomesenchymoma
Central Nervous System Mesenchymal Non-Meningothelial Tumor	Central Nervous System Mesenchymal Non-Meningothelial Tumour Non-Meningothelial Mesenchymal Tumor Non-Meningothelial Mesenchymal Tumour
Small Cell Osteogenic Sarcoma	Small Cell Osteosarcoma Round Cell Osteosarcoma Osteosarcoma Small Cell
Teratoma	Teratomas
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Pulmonary Vein Leiomyosarcoma	Leiomyosarcoma Of The Pulmonary Vein
Retroperitoneal Neuroblastoma
Malignant Olfactory Nerve Neoplasm	Malignant Olfactory Nerve Tumor Malignant Tumor Of Olfactory Nerve Primary Malignant Neoplasm Of Olfactory Nerve
Ewing Sarcoma Of Bone	Ewing'S Sarcoma Of Bone Bone Ewing Sarcoma Bone Ewing'S Sarcoma Bone Localized Ewing Sarcoma Bone Localized Ewing'S Sarcoma Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor Localized Skeletal Ewing'S Sarcoma Localized Bone Ewing Sarcoma
Conventional Osteosarcoma	Intracortical Osteosarcoma Conventional Central Osteosarcoma Intracortical Osteogenic Sarcoma Medullary Osteosarcoma
Ganglioneuroma
Cranial Nerve Malignant Neoplasm	Cranial Nerve Neoplasms Malignant Neoplasm Of Cranial Nerve Malignant Tumor Of Cranial Nerve Malignant Tumor Of The Cranial Nerve
Fibroma
Supratentorial Primitive Neuroectodermal Tumor	Supratentorial Pnet Supratentorial Embryonal Tumor, Not Otherwise Specified Ewings Sarcoma-Primitive Neuroectodermal Tumor
Central Nervous System Primitive Neuroectodermal Neoplasm	Cpnet
Monophasic Synovial Sarcoma	Monophasic Sarcoma Of Synovium
Meninges Hemangiopericytoma	Hemangiopericytoma Of Meninges Meningeal Hemangiopericytoma
Testicular Granulosa Cell Tumor	Granulosa Cell Tumor Of Testis Granulosa Cell Tumour Of Testis Testicular Granulosa Cell Tumour
Extraskeletal Mesenchymal Chondrosarcoma	Mesenchymal Extraosseous Chondrosarcoma
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Congenital Toxoplasmosis	Toxoplasmosis, Congenital Mother-To-Child Transmission Of Toxoplasmosis Toxoplasma Embryofetopathy Toxoplasma Embryopathy Toxoplasmosis - Congen. Toxoplasmosis Congenital
Mesenchymal Chondrosarcoma	Chondrosarcoma, Mesenchymal Chondrosarcoma Mesenchymal
Juvenile Type Testicular Granulosa Cell Tumor	Juvenile Granulosa Cell Tumor Juvenile Granulosa Cell Tumour Juvenile Type Granulosa Cell Neoplasm Juvenile Type Granulosa Cell Tumor Juvenile Type Granulosa Cell Tumour Juvenile Type Testicular Granulosa Cell Tumour
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Biphasic Synovial Sarcoma	Synovial Sarcoma, Biphasic Biphasic Sarcoma Of Synovium
Coccidiosis	Intestinal Coccidiosis Enteric Coccidiosis
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Medulloepithelioma	Diktyoma, Malignant Medulloepithelioma, Central Nervous System Medulloepithelioma Of The Central Nervous System
Rhabdomyosarcoma
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Solitary Fibrous Tumor/Hemangiopericytoma	Sft/Hpc
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Kidney Clear Cell Sarcoma	Clear Cell Sarcoma Of Kidney Childhood Kidney Clear Cell Sarcoma Renal Clear Cell Sarcoma Ccsk Clear Cell Sarcoma Of The Kidney
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-150048	BK50164		/	Unkown
HY-RS02280	CD99 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02281	CD99L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17583	Cd99 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21834	Cd99l2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24043	Cd99 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P991168	Velaprumig	Inhibitor	/	Unkown
HY-P992216	Anti-CD99 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD99	MGD	MGI:1913728
Rattus norvegicus	CD99	RGD	RGD:1594332
Bos taurus	CD99	VGNC	VGNC:50554
Canis familiaris	CD99	VGNC	VGNC:54127