PKNOX1 - PBX/knotted 1 homeobox 1 Gene

Also Known as PREP1; pkonx1c

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5316

About PKNOX1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,974,562-43,033,931 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.8) and 25 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in angiogenesis and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within camera-type eye development; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

PKNOX1 Products (3)

mRNA Protein Name
NM_001286258.2 NP_001273187.1 homeobox protein PKNOX1 isoform 2
NM_001320694.2 NP_001307623.1 homeobox protein PKNOX1 isoform 3
NM_004571.5 NP_004562.2 homeobox protein PKNOX1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
19559479 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKNOX1 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (277 - 316)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
Protein Preferred Names Protein Names

homeobox protein PKNOX1

  • PBX/knotted homeobox 1

PKNOX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PKNOX1 P55347 BORCS6 Homo sapiens Q96GS4
Complementation
32296183
Intra
PKNOX1 P55347 BORCS6 Homo sapiens Q96GS4
Validated Y2H
32296183
Intra
PKNOX1 P55347 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra
PKNOX1 P55347 HMGB2 Homo sapiens P26583
Y2H Prey Pooling
32296183
Intra
PKNOX1 P55347 FAM110B Homo sapiens Q8TC76
Validated Y2H
32296183
Intra
PKNOX1 P55347 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32296183
Intra
PKNOX1 P55347 PBX1 Homo sapiens P40424
Anti Tag CoIP
33961781
Intra
PKNOX1 P55347 PBX1 Homo sapiens P40424
Comigration in SDS
25856340
Intra
PKNOX1 P55347 PBX1 Homo sapiens P40424
GMS
25856340
Intra
PKNOX1 P55347 PBX1 Homo sapiens P40424
Y2H Fragment Pooling
35914814
Intra
PKNOX1 P55347 PBX2 Homo sapiens P40425
Y2H Fragment Pooling
35914814
Intra
PKNOX1 P55347 PBX2 Homo sapiens P40425
Imaging
9482739
Intra
PKNOX1 P55347 PBX2 Homo sapiens P40425
Y2H
19559479
Intra
PKNOX1 P55347 PBX2 Homo sapiens P40425
Anti Tag CoIP
33961781
Intra
PKNOX1 P55347 BLOC1S5 Homo sapiens Q8TDH9
Validated Y2H
32296183
Intra
PKNOX1 P55347 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Intra
PKNOX1 P55347 MPP3 Homo sapiens Q13368
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epilepsy, Familial Temporal Lobe, 4

  • ETL4

  • Epilepsy, Occipitotemporal Lobe, And Migraine With Aura

  • Epolm

  • Familial Temporal Lobe Epilepsy 4

  • Occipitotemporal Lobe Epilepsy And Migraine With Aura
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10609 PKNOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PKNOX1 VGNC VGNC:44614
Macaca mulatta PKNOX1 VGNC VGNC:76150
Felis catus PKNOX1 VGNC VGNC:102804
Rattus norvegicus PKNOX1 RGD RGD:1305003
Bos taurus PKNOX1 VGNC VGNC:32948
Mus musculus PKNOX1 MGD MGI:1201409
Others PKNOX1 NCBI