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ZNF512B - zinc finger protein 512B Gene

Also Known as GM632

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57473

About ZNF512B

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,956,704-63,969,930 (from NCBI)

This gene has 1 transcript (splice variant), 208 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 5.4), thyroid (RPKM 5.3) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and metal ion binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF512B Products (1)

mRNA	Protein	Name
NM_020713.3	NP_065764.1	zinc finger protein 512B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20639536	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20639536	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	20639536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF512B Protein Structure

zf-C2H2_4

0
200
400
600
800
892 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 512B

ZNF512B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ZNF512B	Q96KM6	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	C11orf68	Homo sapiens	Q9H3H3-3	Validated Y2H	32296183
Intra	ZNF512B	Q96KM6	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	ZNF143	Homo sapiens	P52747	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	ZNF143	Homo sapiens	P52747	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	ZNF512B	Q96KM6	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	ZNF512B	Q96KM6	ZYX	Homo sapiens	Q15942	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	ZYX	Homo sapiens	Q15942	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	ZNF512B	Q96KM6	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	FHL3	Homo sapiens	Q13643	Validated Y2H	25416956
Intra	ZNF512B	Q96KM6	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	ZNF512B	Q96KM6	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
Intra	ZNF512B	Q96KM6	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183
Intra	ZNF512B	Q96KM6	AJUBA	Homo sapiens	Q96IF1	Y2H Array	32296183
Intra	ZNF512B	Q96KM6	AJUBA	Homo sapiens	Q96IF1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 40	DFNA40 Autosomal Dominant Nonsyndromic Deafness 40 Autosomal Dominant Deafness 40 Deafness, Autosomal Dominant, 40 Deafness, Autosomal Dominant, Type 40
Nut Allergy	Nut Allergic Reaction Nut Hypersensitivity Allergy To Nuts Allergy Nut
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS16150	ZNF512B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF512B	RGD	RGD:1305284
Canis familiaris	ZNF512B	VGNC	VGNC:48744
Felis catus	ZNF512B	VGNC	VGNC:67316
Mus musculus	ZNF512B	MGD	MGI:2685478
Macaca mulatta	ZNF512B	VGNC	VGNC:79788
Bos taurus	ZNF512B	VGNC	VGNC:37291
Others	ZNF512B	NCBI