hAChE-IN-3
hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE, BuChE， MAO-B-IN-1 and BACE-1 inhibitor, with IC50 values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2983723-56-2
- Formel: C30H24ClN3O5
- Molecular Weight:541.98
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
MAO-B 5.15 μM (IC50) |
AChE 0.44 μM (IC50) |
BChE 0.08 μM (IC50) |
hAChE-IN-3 (compounds 5c) has IC50 values of 36.28 μM (24 h) for SH-SY5Y cell line and 154.10 μM (48 h) for HepG2 cell line[1].
hAChE-IN-3 has IC50 values of 2.58 μM of inhibition of Aβ Aggregation and 59% inhibition at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 2983723-56-2
-
Molecular Weight 541.98
-
Formel C30H24ClN3O5
-
SMILES
O=C(C1=CC=C(Cl)C=C1)COC2=CC3=C(C=C2)C(C4=CC=CC([N+]([O-])=O)=C4)C5=C(N)C6=C(N=C5O3)CCCC6
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
hAChE-IN-3 Related Classifications
HY-155085 Related Classifications
Powered by Bioz