Halazone
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Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water.
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- Reinheit: 75.0%
- CAS. Nr.: 80-13-7
- Formel: C7H5Cl2NO4S
- Molecular Weight:270.09
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Speicherung:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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CA Ⅱ |
Halazone is chemically closely related to Chloramine-T, the nitrogen atom is linked with two instead of one chlorine atom and, certainly more important here, a methyl group is replaced by a carboxyl group. The effect of Halazone on the sodium current is studied in voltage-clamped single nerve fibers of the frog. The oxidant Halazone drastically inhibits inactivation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 80-13-7
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Appearance Solid
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Molecular Weight 270.09
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Formel C7H5Cl2NO4S
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(S(=O)(N(Cl)Cl)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (370.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. M Rack, et al. Effects of Some Chemical Reagents on Sodium Current Inactivation in Myelinated Nerve Fibers of the Frog. Biophys J. 1986 Oct;50(4):557-64. [Content Brief]
[2]. Rema Iyer, et al. Inhibition Profiling of Human Carbonic Anhydrase II by High-Throughput Screening of Structurally Diverse, Biologically Active Compounds. J Biomol Screen. 2006 Oct;11(7):782-91. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7025 mL | 18.5123 mL | 37.0247 mL | 92.5617 mL |
| 5 mM | 0.7405 mL | 3.7025 mL | 7.4049 mL | 18.5123 mL | |
| 10 mM | 0.3702 mL | 1.8512 mL | 3.7025 mL | 9.2562 mL | |
| 15 mM | 0.2468 mL | 1.2342 mL | 2.4683 mL | 6.1708 mL | |
| 20 mM | 0.1851 mL | 0.9256 mL | 1.8512 mL | 4.6281 mL | |
| 25 mM | 0.1481 mL | 0.7405 mL | 1.4810 mL | 3.7025 mL | |
| 30 mM | 0.1234 mL | 0.6171 mL | 1.2342 mL | 3.0854 mL | |
| 40 mM | 0.0926 mL | 0.4628 mL | 0.9256 mL | 2.3140 mL | |
| 50 mM | 0.0740 mL | 0.3702 mL | 0.7405 mL | 1.8512 mL | |
| 60 mM | 0.0617 mL | 0.3085 mL | 0.6171 mL | 1.5427 mL | |
| 80 mM | 0.0463 mL | 0.2314 mL | 0.4628 mL | 1.1570 mL | |
| 100 mM | 0.0370 mL | 0.1851 mL | 0.3702 mL | 0.9256 mL |
Halazone Related Classifications
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