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Art. -Nr.: HY-P99992

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Human IgG1 lambda1, Isotype Control

Name: Human IgG1 lambda1, Isotype Control
Brand: MedChemExpress
SKU: HY-P99992
Price: 200.00 USD
Availability: InStock
Rating: 5 (2 reviews)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Human IgG1 lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG1λ1 antibody. Human IgG1 lambda1, Isotype Control can be used in the research of diabetes and pancreatic cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.64%
Molecular Weight:141.84 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Human IgG1 lambda1, Isotype Control Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Publications Citing Use of MedChemExpress (MCE) Human IgG1 lambda1, Isotype Control

Customer Validation & Images

In Vivo Efficacy StudyBio/Physico-chemical AssayHistological Imaging/Staining

In Vivo Efficacy Study
Bio/Physico-chemical Assay
Histological Imaging/Staining

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Publications (2)
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Human IgG1 lambda1, Isotype Control (48 h before supernatant collection) can be used in macrophages as a control for the inhibitory effect of the human OLR1 blocking antibody Golocdacimab (HY-P99646) on OLR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Human IgG1 lambda1, Isotype Control (20 mg/kg, s.c., once weekly; two doses) can be used as a control for Bimagrumab (HY-P99355) in diabetic pancreatic cancer mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

Appearance Liquid
Molecular Weight 141.84 kDa
Color Colorless to light yellow
SMILES

[Human IgG1 lambda1, Isotype Control]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

All In Vivo Efficacy StudyBio/Physico-chemical AssayHistological Imaging/Staining

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Journal Impact Factor

Nat Commun

Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence. [Abstract]

2025 Sep 30;16(1):8654. PMID: 41027967

Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654. [Abstract]

Pancreatic tumor samples from chow (n = 6 mice per group) and diabetic (n = 9 mice per group) KPC tumor-bearing mice treated with IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks), bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks), or bimagrumab+metformin.

Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654. [Abstract]

Bar graph showing fasting blood glucose changes in diabetic tumor-bearing mice after treatment with 2 doses of IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks), 2 doses of bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks) alone, or 2 doses of bimagrumab combined with 7 doses of metformin (n = 9 mice per group).

Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654. [Abstract]

Representative images and quantification of α-SMA staining (brown) in tumors from chow and diabetic KPC tumor-bearing mice treated with IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks) or bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks) (n = 6 mice per group).
bioRxiv

2025 Aug 28.

Protokoll

All Signal Pathway Related

Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Papachristoforou E, et al. A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver Disease. bioRxiv, 2025: 2025.08. 27.671899.

[2]. Ling YW, et al. Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence. Nat Commun. 2025 Sep 30;16(1):8654. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Human IgG1 lambda1, Isotype Control

2 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Publications (2)
Protokoll
Reinheit & Dokumentation
Verweise

1/16

Product Image
1/16

Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654. [Abstract]

Customer Validation
Pancreatic tumor samples from chow (n = 6 mice per group) and diabetic (n = 9 mice per group) KPC tumor-bearing mice treated with IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks), bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks), or bimagrumab+metformin.
1/16

Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654. [Abstract]

Customer Validation
Bar graph showing fasting blood glucose changes in diabetic tumor-bearing mice after treatment with 2 doses of IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks), 2 doses of bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks) alone, or 2 doses of bimagrumab combined with 7 doses of metformin (n = 9 mice per group).
1/16

Human IgG1 lambda1, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 30;16(1):8654. [Abstract]

Customer Validation
Representative images and quantification of α-SMA staining (brown) in tumors from chow and diabetic KPC tumor-bearing mice treated with IgG (Human IgG1 lambda1, Isotype Control) (20 mg/kg; i.c.; once weekly for 2 weeks) or bimagrumab (20 mg/kg; i.c.; once weekly for 2 weeks) (n = 6 mice per group).
1/16

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Human IgG1 lambda1, Isotype Control

Protein A Agarose

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Publications Citing Use of MedChemExpress (MCE) Human IgG1 lambda1, Isotype Control

Biologische Aktivität

Beschreibung

In Vitro

In Vivo

Conjugated

Reconsititution

Format

Anwendung

Chemical Information

Publications (2)

Protokoll

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Human IgG1 lambda1, Isotype Control Related Classifications

HY-P99992 Related Classifications

Bioz

Keywords

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