IOB-82
IOB-82 is a bifunctional alkylating agent. IOB‑82 induces marked nuclear and cytoplasmic alterations, elicits severe chromatid and chromosome aberrations, and remodels chromosome ploidy. IOB-82 exerts dose-dependent radiomimetic effects and preferentially cytotoxic to large A-type rat ascites cells. IOB-82 can be applied in the research of melanoma‑derived tumors and leukemia.
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- CAS. Nr.: 5977-35-5
- Formel: C12H15Cl2NO2
- Molecular Weight:276.16
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | Survival |
13.9 day
Compound: 4-Me-CABA
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Antitumor activity in BDF1 mouse L1210 cells assessed as mean survival days at 5 mg/kg/day, ip
Antitumor activity in BDF1 mouse L1210 cells assessed as mean survival days at 5 mg/kg/day, ip
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[PMID: 18353651] |
| P388 | Survival |
13.7 day
Compound: 4-Me-CABA
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Antitumor activity in BDF1 mouse bearing P388 cells assessed as mean survival days at 5 mg/kg/day, ip
Antitumor activity in BDF1 mouse bearing P388 cells assessed as mean survival days at 5 mg/kg/day, ip
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[PMID: 18353651] |
IOB-82 (3.62 × 10, 4-3.62 × 10-3 μM/mL; 24 h) induces concentration-dependent morphological damage to HR-18 rat ascites cells, with large A-type cells more severely affected than B-type cells[2].
IOB-82 (3.62 × 10-4, 3.62 × 10-3 μM/mL; 24 h) induces concentration-dependent structural and numerical chromosomal damage to HR-18 rat ascites cells, eliminating polyploid cells and the 85-86 chromosome population, increasing cells with 41-49 chromosomes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 5977-35-5
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Molecular Weight 276.16
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Formel C12H15Cl2NO2
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SMILES
O=C(C1=CC=C(C)C(N(CCCl)CCCl)=C1)O
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Synonyms
NSC-146171
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kapou A, et al. 3D QSAR/CoMFA and CoMSIA studies on antileukemic steroidal esters coupled with conformationally flexible nitrogen mustards. J Chem Inf Model. 2008;48(11):2254-2264. [Content Brief]
[2]. Dumitrescu L, et al. Morphological and cytogenetical changes in HR-18 rat ascites cells after in vitro 3-[bis(2-chloroethyl)amino]-4-methylbenzoic acid (NSC-146171; IOB-82) administration. Tumori. 1978;64(4):361-370. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IOB-82 Related Classifications
HY-182682 Related Classifications
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- IOB-82
- 5977-35-5
- NSC-146171
- IOB82
- IOB 82
- NSC146171
- NSC 146171
- DNA Alkylator/Crosslinker
- nitrogen mustard
- alkylating agent
- HR-18 rat ascites cells
- steroidal mustard ester
- A-type rat ascites cells
- chromosome aberrations
- chromatid aberrations
- melanocarcinoma
- B-type rat ascites cells
- leukemia p388
- Inhibitor
- inhibitor
- inhibit