KRAS-IN-43
KRAS-IN-43 (Compound 9) is a pan-KRAS inhibitor with IC50 values of 0.15 μM, 0.14 μM, and 0.47 μM against KRASG12V, KRASG12C and wild-type KRAS, respectively. KRAS-IN-43 disrupts the interaction between KRAS and cRAF, and inhibits ERK phosphorylation. KRAS-IN-43 is promising for research of KRAS mutation-related cancers (such as pancreatic cancer, colorectal cancer, and lung cancer).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C30H29FN2O3
- Molecular Weight:484.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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KRas G12V 0.15 μM (IC50) |
KRas G12C 0.14 μM (IC50) |
K-Ras WT 0.47 μM (IC50) |
Chemical Information
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Molecular Weight 484.56
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Formel C30H29FN2O3
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SMILES
C#CC1=C(C=CC2=CC(O)=CC(C(N3CCC4=C(C3)C=CC=C4OCC56CCCN5CCC6)=O)=C21)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KRAS-IN-43 Related Classifications
HY-176250 Related Classifications
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