KVL-9
KVL-9 is an intermediate used for constructing KRAS degrading antibody conjugates (DACs). KVL-9 consists of a KRAS small molecule binder, spacer, VHL recruitment ligand, and a cleavable antibody linker. KVL-9 achieves antigen-dependent intracellular delivery and induces ubiquitin-proteasome degradation of the KRAS protein mediated by VHL by conjugating with tumor antigen-targeting antibodies.
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- CAS. Nr.: 3113309-33-1
- Formel: C140H192F2N38O34S2
- Molecular Weight:3053.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 3113309-33-1
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Molecular Weight 3053.38
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Formel C140H192F2N38O34S2
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SMILES
C[C@@]1(C2=NC(C3=NC(N4[C@H](CN(CCC4)CCCCOC5=CN(N=N5)[C@@H](C(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=C(C=C(C8=C(C)N=CS8)C(F)=C7)OCC9=CC=C(C=C9)NC([C@H](C)NC([C@H](C)NC(CCC%10=C(C(F)=C(N%11C(C=CC%11=O)=O)C=C%10)OCCCC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)C)=NC=C3)=NO2)C%12=C(CCC1)SC(N)=C%12C#N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KVL-9 Related Classifications
HY-186226 Related Classifications
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