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Art. -Nr.: HY-N3393

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Lethedioside A

Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC₅₀ of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells.

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CAS. Nr.: 221289-31-2
Formel: C₂₉H₃₄O₁₅
Molecular Weight:622.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Lethedioside A Chemical Structure

CAS. Nr.: 221289-31-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Hes1

9.5 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	>100 μg/mL Compound: 4	Cytotoxicity against human KB cells after 72 hrs by neutral red assay Cytotoxicity against human KB cells after 72 hrs by neutral red assay	[PMID: 10075750]

In Vitro

Lethedioside A (compound 4) weakly inhibits purified hTCF4/β-catenin complex formation in a cell-free ELISA with an IC₅₀ of 46.9 μM^[1].
Lethedioside A binds directly to GST-Hes1 immobilized on Sepharose beads in a cell-free biochemical binding assay^[1].
Lethedioside A (24 h) potently inhibits LPS (HY-D1056)-induced nitric oxide production in RAW 264.7 macrophages with an IC₅₀ of 7.91 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 221289-31-2
Molecular Weight 622.57
Formel C₂₉H₃₄O₁₅
SMILES

O=C1C(C(OC(C2=CC(OC)=C(OC)C=C2)=C1)=CC(OC)=C3)=C3O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@H]([C@H](O)CO5)O)O
Structure Classification
- Flavonoids
- Flavones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Arai MA, et al. Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells. Chem Sci. 2016;7(2):1514-1520. [Content Brief]

[2]. Dong CHEN, et al. Flavanoids from the stems of Aquilaria sinensis. Chinese Journal of Natural Medicines. Volume 10, Issue 4, July 2012, Pages 287-291.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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