Mandipropamid
Based on 1 Customer Validation
Mandipropamid is a cellulose synthase (CesA3) inhibitor and fungicide, with an IC50 of 19.8 nM against Phytophthora infestans. Mandipropamid inhibits the synthesis of crystalline cellulose on the cell surface, disrupts the cell wall structure of oomycetes, and induces germ tube tip swelling and growth arrest in Phytophthora infestans. S-Mandipropamid, an isomer of Mandipropamid, exhibits enantioselective acute toxicity to zebrafish embryos and larvae. Mandipropamid is applicable to studies related to plant infections.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.58%
- CAS. Nr.: 374726-62-2
- Formel: C23H22ClNO4
- Molecular Weight:411.88
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-B2011
FlutolanilFungicide -
HY-134094
FluridoneABA Biosynthesis Inhibitor -
HY-116541
Acibenzolar-S-methylPlant Activator -
HY-134094R
Fluridone (Standard)ABA Biosynthesis Inhibitor -
HY-B2011R
Flutolanil (Standard)Standard -
HY-W744966R
Mandipropamid (Standard)Reference Standard -
HY-120253
SpirotetramatInsecticide -
HY-116541R
Acibenzolar-S-methyl (Standard)Reference Standard -
HY-120253R
Spirotetramat (Standard)Pesticide
Biologische Aktivität
Beschreibung
In Vitro
The EC50 of S-Mandipropamid for 7-day growth inhibition of Spirodela polyrhiza is 14.86 mg/L[2].
Mandipropamid (MPD) (68 nM; 1-3 h) induces reversible growth arrest and swelling of germ tube tips in germinated Phytophthora infestans sporangia[1].
Mandipropamid causes the Phytophthora infestans mutant strains Tmut3 and Tmut7 to exhibit a resistance factor of over 1512-fold against its induced inhibition of germ tube length, with their IC50 values exceeding 121 μM, whereas the IC50 value of the wild-type T30-4 strain is 0.08 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 374726-62-2
-
Appearance Solid
-
Molecular Weight 411.88
-
Formel C23H22ClNO4
-
Color Off-white to light yellow
-
SMILES
O=C(C(C1=CC=C(C=C1)Cl)OCC#C)NCCC2=CC=C(C(OC)=C2)OCC#C
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (242.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (284 KB)
-
SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Blum M, et al. Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans. Molecular plant pathology. 2010 Mar;11(2):227-43. [Content Brief]
[2]. Zhang J, et al. Enantioselective Bioactivity, Toxicity, and Degradation in Vegetables and Soil of Chiral Fungicide Mandipropamid. Journal of agricultural and food chemistry. 2021 Nov 17;69(45):13416-13424. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4279 mL | 12.1395 mL | 24.2789 mL | 60.6973 mL |
| 5 mM | 0.4856 mL | 2.4279 mL | 4.8558 mL | 12.1395 mL | |
| 10 mM | 0.2428 mL | 1.2139 mL | 2.4279 mL | 6.0697 mL | |
| 15 mM | 0.1619 mL | 0.8093 mL | 1.6186 mL | 4.0465 mL | |
| 20 mM | 0.1214 mL | 0.6070 mL | 1.2139 mL | 3.0349 mL | |
| 25 mM | 0.0971 mL | 0.4856 mL | 0.9712 mL | 2.4279 mL | |
| 30 mM | 0.0809 mL | 0.4046 mL | 0.8093 mL | 2.0232 mL | |
| 40 mM | 0.0607 mL | 0.3035 mL | 0.6070 mL | 1.5174 mL | |
| 50 mM | 0.0486 mL | 0.2428 mL | 0.4856 mL | 1.2139 mL | |
| 60 mM | 0.0405 mL | 0.2023 mL | 0.4046 mL | 1.0116 mL | |
| 80 mM | 0.0303 mL | 0.1517 mL | 0.3035 mL | 0.7587 mL | |
| 100 mM | 0.0243 mL | 0.1214 mL | 0.2428 mL | 0.6070 mL |
Mandipropamid Related Classifications
HY-W744966 Related Classifications
Powered by Bioz