MDI-117740
MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C24H24N4O2
- Molecular Weight:400.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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LIMK1 7.80 (pKd) |
LIMK2 7.12 (pKd) |
LIMK1 6.73 (pIC50) |
LIMK2 7.18 (pIC50) |
MDI-117740 exhibits potent binding affinity to LIMK1 (pKd = 7.80) and LIMK2 (pKd = 7.12) as well as effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells[1].
MDI-117740 (2 h) potently inhibits cofilin phosphorylation (p-cofilin) in SH-SY5Y cells, with a pIC50 value of 6.89[1].
MDI-117740 (0.25-3 μM, 48 h) exerts significant anti-migratory activity in MDA-MB-231 cells via wound healing assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 400.47
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Formel C24H24N4O2
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SMILES
O=C(C1=C(CCN2[C@H](C3CC3)C4=CC=CC=C4)C(C2=O)=NN1CC5=CC=CC=C5)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MDI-117740 Related Classifications
HY-175656 Related Classifications
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