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Art. -Nr.: HY-N21574

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Milliamine D

Milliamine D is a diterpenoid toxin of the ingenol ester class containing an anthraniloyl tripeptide, existing in the free base form and exhibiting molluscicidal activity. Milliamine D can be used in the study of schistosomiasis.

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CAS. Nr.: 88524-59-8
Formel: C₄₅H₄₉N₃O₁₀
Molecular Weight:791.88

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Milliamine D Chemical Structure

CAS. Nr.: 88524-59-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Milliamine D (compound 7) (100 μg/L; 24 h) kills 100% of Biomphalaria glabrata snails^[2].

Others

Milliamine D is a 5,20-diester of ingenol, featuring an anthraniloyl tripeptide side chain with a terminal N,N-dimethylamino group and an acetyl group at position 20^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Milliamine D (0.18 nmol; topical application; single administration) induces ear irritation in mice, with an ID₅₀²⁴of 0.18 nmol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NMRI (ear irritation assay; tumour promotion tests strain)^[1]
Dosage:

0.18 nmol
Administration:

topical; single application
Result:

Was determined to have a 24-hour irritant dose 50 of 0.18 nmol for ear irritation.
Exhibited an irritancy (I²⁴ = 1/ID₅₀²⁴) of 5.6 nmol^-1.

Chemical Information

CAS. Nr. 88524-59-8
Molecular Weight 791.88
Formel C₄₅H₄₉N₃O₁₀
SMILES

O=C(O[C@@H]1C(COC(C)=O)=C[C@](C2=O)([H])[C@@]3([H])[C@@](C3(C)C)([H])C[C@@H](C)[C@@]42[C@]1(O)[C@@H](O)C(C)=C4)C5=CC=CC=C5NC(C6=CC=CC(O)=C6NC(C7=CC=CC=C7N(C)C)=O)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Marston A, et al. On the Active Principles of the Euphorbiaceae VI: Isolation and Biological Activities of Seven Milliamines from Euphorbia milii. Planta Med,1983,47(3):141-147.

[2]. Carlos Leomar Zani, et al. Molluscicidal milliamines from Euphorbia milii var. hislopii, Phytochemistry,
Volume 34, Issue 1, 1993, Pages 89-95, ISSN 0031-9422.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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