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Art. -Nr.: HY-182643

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NO-794

NO-794 is a histamine H₂ receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers.

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CAS. Nr.: 105150-87-6
Formel: C₂₃H₂₈N₄O₂
Molecular Weight:392.49

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NO-794 Chemical Structure

CAS. Nr.: 105150-87-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

NO-794 is a histamine H₂ receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers^[1].

IC₅₀ & Target^[1]

H₂ Receptor

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

NO-794 (0-30 min) is a potent, time-dependent and irreversible histamine H₂ receptor antagonist acting on dispersed guinea pig gastric mucosal cells, with a -log K_B value of 8.4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NO-794 (0.5-2 mg/kg; intradermal injection; single administration) potently inhibits gastric acid secretion in pylorus-ligated rats, with an ED₅₀ of 0.9 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 180-210 g, pylorus-ligated model)^[1]
Dosage:

0.5 mg/kg; 1.0 mg/kg; 2 mg/kg
Administration:

i.d.; single dose
Result:

Reduced gastric acid output compared to controls at 0.5 mg/kg.
Significantly reduced gastric acid output by greater margins at 1.0 mg/kg and 2.0 mg/kg.
Achieved an ED50 value of 0.9 mg/kg for reduction of gastric acid secretion.
Demonstrated approximately 14 times more potency than ranitidine.

Chemical Information

CAS. Nr. 105150-87-6
Molecular Weight 392.49
Formel C₂₃H₂₈N₄O₂
SMILES

O=C1NC(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=C1C=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Oshita M, et al. Pharmacological studies of 2-(3-(3-(1-piperidinylmethyl)-phenoxy)propylamino)-4 (3H)-quinazolinone (NO-794), a new histamine H2-receptor antagonist. Jpn J Pharmacol. 1986 Oct;42(2):229-35. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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NO-794

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

NO-794 Related Classifications

HY-182643 Related Classifications