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Art. -Nr.: HY-158423

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NPD8790

NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC₅₀ of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths.

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CAS. Nr.: 615281-26-0
Formel: C₂₀H₂₄N₂
Molecular Weight:292.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NPD8790 Chemical Structure

CAS. Nr.: 615281-26-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

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In Vitro

NPD8790 shows marks species selectivity, inhibiting C. elegans complex I (IC₅₀ = 2.4 µM) more potently than complex I from either bovine (IC₅₀ = 27.2 µM), murine heart mitochondria (IC₅₀ = 28.8 µM) or human mitochondria (IC₅₀ > 75 μM)^[1].
NPD8790 against complex I is similar for all nematode species (C. briggsae, IC₅₀ = 1.6 μM; P. pacificus, IC₅₀ = 2.1 μM; P. hermaphrodita, IC₅₀ = 1.1 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 615281-26-0
Molecular Weight 292.42
Formel C₂₀H₂₄N₂
SMILES

CC(CC1=CC=C(C=C1)C(C2=NC3=C(N2C)C=CC=C3)C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Taylor Davie, et al. Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nat Commun. 2024 May 8;15(1):3367. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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