NSC804515
NSC804515 is an inhibitor of wild-type and R155H mutant p97/VCP ATPase, with an IC50 of about 15 nM for both targets. NSC804515 acts as an antiproliferative agent, disrupts the function of the ubiquitin-proteasome system, induces UbG76V-GFP accumulation, and shows reduced inhibitory potency against p97 variants carrying P510S, K512N, N616F and F618S mutations. NSC804515 can be used in research related to cancer, inclusion body myopathy with early-onset Paget's disease and frontotemporal dementia, as well as familial amyotrophic lateral sclerosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C26H25F2N5O2S
- Molecular Weight:509.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
In Vitro
NSC804515 exhibits drastically reduced inhibitory potency against purified human p97 resistance mutants p97P510S, p97N616F, and p97F618S (over 30-fold higher IC50) and p97K512N (12-fold higher IC50) compared to wild-type p97[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 509.57
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Formel C26H25F2N5O2S
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SMILES
FC1=CC(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CN=CC=C4)=C(F)C=C1C#CCNC(CC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NSC804515 Related Classifications
HY-168007 Related Classifications
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Keywords
- NSC804515
- NSC 804515
- NSC-804515
- p97
- p97R155H
- R155H mutant human p97/VCP ATPase
- cancer
- UbG76V-GFP
- p97WT
- inclusion body myopathy with early-onset paget disease and frontotemporal dementia
- familial amyotrophic lateral sclerosis
- ubiquitin-proteasome system
- human p97/VCP ATPase
- D1-D2 domain interface
- Inhibitor
- inhibitor
- inhibit