NUCC-555
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice.
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- CAS. Nr.: 1060469-90-0
- Formel: C25H25N5O3
- Molecular Weight:443.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
12.1 μM
Compound: NUCC-555
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Induction of apoptosis in human HepG2 cells assessed as cell viability after 96 hrs by MTT assay
Induction of apoptosis in human HepG2 cells assessed as cell viability after 96 hrs by MTT assay
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[PMID: 26098096] |
Chemical Information
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CAS. Nr. 1060469-90-0
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Molecular Weight 443.50
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Formel C25H25N5O3
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SMILES
O=C(NCC1=CC=CC=C1)C2=CC(NC(COC)=O)=CC3=C2N(C(C4=CC=CN=C4)=N3)CC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NUCC-555 Related Classifications
HY-122179 Related Classifications
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