OGT-719
OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 185843-61-2
- Formel: C10H13FN2O7
- Molecular Weight:292.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
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Biologische Aktivität
Beschreibung
In Vitro
OGT-719 (80 mM, 4 h) inhibits thymidylate synthase (TS) activity in C170HM2 cells at a concentration of 80 mM (approximately 2xIC50)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male MFI nude mice injected with C170HM2 cells into the peritoneal cavity[1]
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Dosage:1500 mg/kg/day
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Administration:p.o., b.i.d. for 32 days
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Result:Showed a significant 70% reduction in mean liver tumor burden.
Showed a significant decrease in mean liver tumor cross-sectional areas.
Showed no significant effect on animal weight.
Chemical Information
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CAS. Nr. 185843-61-2
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Molecular Weight 292.22
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Formel C10H13FN2O7
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SMILES
O=C1NC(C(F)=CN1[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO)O2)O)O)O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
OGT-719 Related Classifications
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