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Pavurutamab

(Synonyms: AMG-701)
1 Cited Publications
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Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM).

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  • Reinheit: 99.9%
  • CAS. Nr.: 2250292-39-6
  • Molecular Weight:105.78 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pavurutamab
  • Experimental Validation Results for Pavurutamab
  • Experimental Validation Results for Pavurutamab
  • Experimental Validation Results for Pavurutamab
  • Pavurutamab Chemical Structure
    Pavurutamab Chemical Structure
CAS. Nr.: 2250292-39-6
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609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc

  • 1/16

    Immobilized Pavurutamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 1.26 ng/mL.

  • 1/16

    Immobilized Pavurutamab can bind Human BCMA Protein (ECD, His Tag). The EC50 for this effect is 0.194 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Pavurutamab (HY-P99814). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Pavurutamab Chemical Structure
    1/16
  • Pavurutamab
  • Immobilized Pavurutamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 1.26 ng/mL.
  • Immobilized Pavurutamab can bind Human BCMA Protein (ECD, His Tag). The EC50 for this effect is 0.194 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Pavurutamab (HY-P99814). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc