PD-135666
PD-135666 is a dipeptide inhibitor of cholecystokinin B (CCK B) receptors, binding to CCK B receptors in mouse cerebral cortex with IC50 of 0.1 nM. Its enantiomer, PD-140548, preferentially binds to CCK A receptors with IC50 of 2.8 nM in rat pancreas. PD-135666 exhibits anxiolytic effects in animal models.
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- CAS. Nr.: 134557-41-8
- Formel: C33H39N3O5
- Molecular Weight:557.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 0.1 nM (CCK B Receptor)[1]
Chemical Information
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CAS. Nr. 134557-41-8
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Molecular Weight 557.68
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Formel C33H39N3O5
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SMILES
O=C(C[C@H](CC1=CC=CC=C1)NC([C@](NC(OC2C3CC4CC(CC2C4)C3)=O)(CC5=CNC6=C5C=CC=C6)C)=O)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PD-135666 Related Classifications
HY-117839 Related Classifications
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