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Art. -Nr.: HY-N11008

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Physagulide J

Physagulide J is a kind of withanolides compound that can be isolated from Physalis angulata L.. Many kinds of active ingredients of Physalis angulata L. shows anti-inflammatory and anti-tumor activity.

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CAS. Nr.: 1496524-09-4
Formel: C₃₀H₄₀O₇
Molecular Weight:512.63

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Physagulide J Chemical Structure

CAS. Nr.: 1496524-09-4

Größe

Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	0.39 μM Compound: 17	Antiproliferative activity against human 786-0 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human 786-0 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
A498	IC₅₀	0.71 μM Compound: 17	Antiproliferative activity against human A498 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human A498 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
ACHN	IC₅₀	0.73 μM Compound: 17	Antiproliferative activity against human ACHN cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human ACHN cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
CWR22R	IC₅₀	0.9 μM Compound: 17	Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
LNCaP C4-2B	IC₅₀	0.49 μM Compound: 17	Antiproliferative activity against human C4-2B cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human C4-2B cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
RAW264.7	IC₅₀	1.36 μM Compound: 17	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 27295506]

Chemical Information

CAS. Nr. 1496524-09-4
Molecular Weight 512.63
Formel C₃₀H₄₀O₇
SMILES

CC(C[C@H]([C@H]([C@H]1C[C@@H]([C@]2([C@@H]3C[C@H]4O[C@]45CC=CC([C@@]5([C@H]3CC[C@@]21C)C)=O)O)OC(C)=O)C)O6)=C(C)C6=O
Structure Classification
- Steroids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Signal Pathway Related

Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sun CP, et al. Antiproliferative and Anti-inflammatory Withanolides from Physalis angulata. J Nat Prod. 2016 Jun 24;79(6):1586-97. [Content Brief]

[2]. 孙成鹏. 苦蘵的化学成分及其抗肿瘤和抗炎活性研究. 沈阳药科大学, 2016.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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