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Art. -Nr.: HY-184755

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Poly(methacrylic acid)

(Synonyms: PMAA)

Poly(methacrylic acid) (PMAA) is a pH/ionic strength-responsive swelling agent and polycation complexing agent. Poly(methacrylic acid) undergoes reversible swelling and size changes through carboxylic acid ionization and sodium ion charge shielding. As a weak polyacid, Poly(methacrylic acid) forms cross-linked hydrogels and hollow capsules for the entrapment and storage of macromolecules. Poly(methacrylic acid) forms electrostatic complexes with polycations to reduce capsule permeability, and high-salt conditions disrupt such complexes to enable macromolecule release.

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CAS. Nr.: 25087-26-7
Formel: (C₄H₆O₂)_n

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Poly(methacrylic acid) Chemical Structure

CAS. Nr.: 25087-26-7

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Poly(methacrylic acid) can serve as a biocompatible hydrogel matrix to achieve non-Fickian, pH-dependent in vitro controlled release of Metoclopramide hydrochloride (HY-17382)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 25087-26-7
Formel (C₄H₆O₂)_n
SMILES

CCC(C)(C(O)=O)C.[n]
Synonyms

PMAA
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kozlovskaya V, Kharlampieva E, Mansfield M L, et al. Poly (methacrylic acid) hydrogel films and capsules: response to pH and ionic strength, and encapsulation of macromolecules[J]. Chemistry of materials, 2006, 18(2): 328-336.

[2]. Gunther EC, et al. Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists. Cell Rep. 2019 Jan 2;26(1):145-158.e8. [Content Brief]

[3]. Garcıa D M, et al. Synthesis and characterization of poly (methacrylic acid) hydrogels for metoclopramide delivery[J]. European Polymer Journal, 2004, 40(8): 1637-1643.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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