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Art. -Nr.: HY-105628

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Prodilidine

Name: Prodilidine
Brand: MedChemExpress
SKU: HY-105628
Availability: PreOrder

(Synonyms: CI-427)

Prodilidine (CI-427) is an orally active, pyrrolidine-derived non-narcotic pain inhibitor. Prodilidine exerts analgesic activity against various nociceptive stimuli, and shows no antipyretic, anti-inflammatory or respiratory depressive effects. Prodilidine fails to inhibit withdrawal symptoms of addictive agents in monkeys, but exhibits excitatory effects and enhances the crossed extensor reflex at toxic doses. Prodilidine is well absorbed from the gastrointestinal tract and metabolized via hepatic microsomal N-demethylation, displaying isomer-specific activity, toxicity and metabolic characteristics. Prodilidine can be used in research related to chronic pain (e.g., cancer-, musculoskeletal/arthritis-derived), traumatic pain and arthritic pain.

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CAS. Nr.: 3734-17-6
Formel: C₁₅H₂₁NO₂
Molecular Weight:247.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Prodilidine Chemical Structure

CAS. Nr.: 3734-17-6

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Prodilidine undergoes N-demethylation via liver microsomes from multiple species, with the (-)-Prodilidine showing greater demethylation than the (+)-Prodilidine by rat liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Prodilidine hydrochloride (7.2-84.0 mg/kg; p.o.; s.c.; i.v.) exhibits analgesic activity in mice, with ED₅₀ values ranging from 7.2 mg/kg (subcutaneous, writhing assay) to 84.0 mg/kg (oral, tail-pinch assay), and LD₅₀ values ranging from 91 mg/kg (intravenous) to 318 mg/kg (oral)^[1].
Prodilidine hydrochloride (11.2-17.8 mg/kg; p.o.; s.c.; i.v.) exhibits analgesic activity in rats, with ED₅₀ values ranging from 11.2 mg/kg (intravenous) to 17.3 mg/kg (oral) in the tail-flick assay, and LD₅₀ values ranging from 74 mg/kg (intravenous) to 253 mg/kg (oral)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[1]
Dosage:

84.0 mg/kg (tail-pinch assay, p.o.); 72.3 mg/kg (tail-pinch assay, s.c.); 30.0 mg/kg (tail-pinch assay, i.v.); 7.2 mg/kg (writhing assay, s.c.); 318 mg/kg (LD₅₀, p.o.); 194 mg/kg (LD₅₀, s.c.); 91 mg/kg (LD₅₀, i.v.)
Administration:

p.o. (tail-pinch assay); s.c. (tail-pinch assay, writhing assay); i.v. (tail-pinch assay)
Result:

Achieved an ED₅₀ of 84.0 mg/kg orally in the tail-pinch assay.
Achieved an ED₅₀ of 72.3 mg/kg subcutaneously in the tail-pinch assay.
Achieved an ED₅₀ of 30.0 mg/kg intravenously in the tail-pinch assay.
Achieved an ED₅₀ of 7.2 mg/kg subcutaneously in the writhing assay.
Reached an LD₅₀ of 318 mg/kg orally in mice.
Reached an LD₅₀ of 194 mg/kg subcutaneously in mice.
Reached an LD₅₀ of 91 mg/kg intravenously in mice.

Chemical Information

CAS. Nr. 3734-17-6
Molecular Weight 247.34
Formel C₁₅H₂₁NO₂
SMILES

O=C(OC1(C=2C=CC=CC2)CCN(C)C1C)CC
Synonyms

CI-427
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Eddy N B. Codeine and its alternates for pain and cough relief[J]. Annals of Internal Medicine, 1969, 71(6): 1209-1212.

[2]. Kissel J W, et al. The pharmacology of prodilidine hydrochloride, a new analgetic agent[J]. The Journal of Pharmacology and Experimental Therapeutics, 1961, 134(3): 332-340.

[3]. Winder C V, et al. Pharmacologic and toxicologic studies of m-(1-methyl-3-propyl-3-pyrrolidinyl) phenol (CI-572), an analgetic and antitussive agent[J]. The Journal of Pharmacology and Experimental Therapeutics, 1966, 154(1): 161-175.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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