PROTAC KAT6 Degrader-1
PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. PROTAC KAT6 Degrader-1 inhibits cancer cells proliferation.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C39H46FN9O7S
- Molecular Weight:803.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Cereblon |
MOZ/MORF |
In Vitro
PROTAC KAT6 Degrader-1 (Compound 28) (12 nM) shows maximal fold activity ≥7.0 of ternary complex formation[1].
PROTAC KAT6 Degrader-1 inhibits T47D cell proliferation with GI50 of 10.3 nM[1].
(Pink: target protein ligand; Blue: E3 ligase ligand; Black: linker).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 803.90
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Formel C39H46FN9O7S
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SMILES
COC1=CC(N2CCN(CC2)CC(CC3)CCN3C4=CC=C(NC5C(NC(CC5)=O)=O)C=C4F)=CC=C1S(=O)(NC(C6=CC=C(C(OC)=N6)CN7C=CC=N7)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PROTAC KAT6 Degrader-1 Related Classifications
HY-182775 Related Classifications
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