CD105
CD105, better known as endoglin, is a type I membrane glycoprotein that serves as an accessory receptor in the TGF-beta superfamily signaling system. Highly enriched on proliferating endothelial cells, it pairs with ALK1 and ALK5 to balance endothelial proliferation and quiescence during angiogenesis. Homozygous ENG disruption causes vascular dysplasia, and heterozygous mutations underlie hereditary hemorrhagic telangiectasia type 1, a disorder marked by recurrent nosebleeds and arteriovenous malformations. Since CD105 density reflects neovascular activity, the molecule is widely used as a marker of tumor angiogenesis and as a target for antibody-drug conjugates. The protein forms disulfide-linked homodimers on the cell surface.
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CD105 Recombinant Proteins (4)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
