CD53
CD53 is a four-pass transmembrane protein of the tetraspanin family expressed broadly on leukocytes, including lymphocytes, monocytes, granulocytes and dendritic cells. Residing within tetraspanin-enriched membrane microdomains, it associates with integrins, CD4, CD8 and MHC molecules, organizing surface receptor clusters that strengthen adhesion and antigen-driven signaling. Loss-of-function mutations in TSPAN7, the gene encoding CD53, cause an X-linked immunodeficiency characterized by recurrent infections and impaired B-cell memory, underscoring a nonredundant role in human immunity. Flow-cytometric anti-CD53 antibodies serve as pan-leukocyte markers comparable to CD45 for immunophenotyping.
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CD53 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
