CLEC-2
CLEC-2 (CLEC1B) is a platelet activation receptor best known for binding the transmembrane glycoprotein podoplanin. A single hemITAM in its cytoplasmic tail recruits Syk and Slp-76, driving platelet aggregation and spreading upon engagement by podoplanin or by the snake C-type lectin rhodocytin. Beyond hemostasis, CLEC-2 signaling is essential for blood-lymphatic separation during development and has been implicated in tumor metastasis, where podoplanin-expressing cancer cells co-opt platelets. Within the C-type lectin family it stands out for this unique activation motif shared only with a few related receptors. Recombinant CLEC-2 is used to study podoplanin interactions, platelet signaling, and metastatic niches.
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CLEC-2 Recombinant Proteins (3)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
