DAPK
The DAPK group comprises death-associated protein kinases, calcium/calmodulin-regulated serine/threonine kinases defined by an N-terminal kinase domain, a calmodulin-binding regulatory segment, and cytoskeletal-interaction motifs. DAPK1, the founding member, carries ankyrin repeats and a death domain and promotes apoptosis downstream of interferon-gamma and tumor necrosis factor signaling, phosphorylating myosin regulatory light chain during membrane blebbing. The group also includes DAPK2, DAPK3, and the DRAK kinases. DAPK family members act as tumor suppressors, and their promoter methylation occurs frequently in cancers. They additionally regulate autophagy, anoikis, and inflammation, positioning them at the interface between cell death and survival decisions.
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DAPK Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
